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Cancer Manag Res. 2018 May 14;10:1143-1154. doi: 10.2147/CMAR.S155283. eCollection 2018.

[No title available]

Cancer management and research

Elena Tagliabue, Sara Gandini, Rino Bellocco, Patrick Maisonneuve, Julia Newton-Bishop, David Polsky, DeAnn Lazovich, Peter A Kanetsky, Paola Ghiorzo, Nelleke A Gruis, Maria Teresa Landi, Chiara Menin, Maria Concetta Fargnoli, Jose Carlos García-Borrón, Jiali Han, Julian Little, Francesco Sera, Sara Raimondi

Affiliations

  1. Clinical Trial Center, Scientific Directorate, Fondazione IRCCS Istituto Nazionale dei Tumori.
  2. Division of Epidemiology and Biostatistics, European Institute of Oncology, Milan, Italy.
  3. Department of Medical Epidemiology and Biostatistics, Karolinska Institutet, Stockholm, Sweden.
  4. Department of Statistics and Quantitative Methods, University of Milano-Bicocca, Milan, Italy.
  5. Section of Epidemiology and Biostatistics, Institute of Cancer and Pathology, University of Leeds, Leeds, UK.
  6. Ronald O. Perelman Department of Dermatology, New York University School of Medicine, NYU Langone Medical Center, New York, NY.
  7. Division of Epidemiology and Community Health, University of Minnesota, MN.
  8. Department of Cancer Epidemiology, H Lee Moffitt Cancer Center and Research Institute, Tampa, FL, USA.
  9. Department of Internal Medicine and Medical Specialties, University of Genoa.
  10. IRCCS AOU San Martino-IST, Genoa, Italy.
  11. Department of Dermatology, Leiden University Medical Center, Leiden, the Netherlands.
  12. Division of Cancer Epidemiology and Genetics, National Cancer Institute, NIH, Bethesda, MD, USA.
  13. Immunology and Molecular Oncology Unit, Veneto Institute of Oncology, IOV-IRCCS, Padua.
  14. Department of Dermatology, University of L'Aquila, L'Aquila, Italy.
  15. Department of Biochemistry, Molecular Biology, and Immunology, University of Murcia.
  16. IMIB-Arrixaca, Murcia, Spain.
  17. Department of Epidemiology, Richard M Fairbanks School of Public Health, Melvin and Bren Simon Cancer Center, Indiana University, Indianapolis, IN, USA.
  18. School of Epidemiology and Public Health, University of Ottawa, Ottawa, ON, Canada.
  19. Department of Social and Environmental Health Research, London School of Hygiene and Tropical Medicine, London, UK.

PMID: 29795986 PMCID: PMC5958947 DOI: 10.2147/CMAR.S155283

Abstract

PURPOSE: Melanoma represents an important public health problem, due to its high case-fatality rate. Identification of individuals at high risk would be of major interest to improve early diagnosis and ultimately survival. The aim of this study was to evaluate whether

MATERIALS AND METHODS: Data were collected within an international collaboration - the M-SKIP project. The present pooled analysis included data on 3,830 single, primary, sporadic, cutaneous melanoma cases and 2,619 controls from seven previously published case-control studies. All the studies had information on

RESULTS: The presence of any

CONCLUSION: The authors suggest that measuring the

Keywords: cutaneous melanoma; genetic epidemiology; melanocortin 1 receptor; pigmentation; pooled analysis

Conflict of interest statement

Disclosure The authors report no conflicts of interest in this work.

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