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Khaleghizadeh M, Forghanifard MM, Rad A, et al. Ectopic Expression of Human . Avicenna J Med Biotechnol. 2018;10(2):75-82
Khaleghizadeh, M., Forghanifard, M. M., Rad, A., Farshchian, M., Hejazi, Z., Gholamin, M., Memar, B., & Abbaszadegan, M. R. (2018). Ectopic Expression of Human . Avicenna journal of medical biotechnology, 10(2), 75-82.
Khaleghizadeh, Maryam, et al. "Ectopic Expression of Human ." Avicenna journal of medical biotechnology vol. 10,2 (2018): 75-82.
Khaleghizadeh M, Forghanifard MM, Rad A, Farshchian M, Hejazi Z, Gholamin M, Memar B, Abbaszadegan MR. Ectopic Expression of Human . Avicenna J Med Biotechnol. 2018 Apr-Jun;10(2):75-82. PMID: 29849983; PMCID: PMC5960063.
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Avicenna J Med Biotechnol. 2018 Apr-Jun;10(2):75-82.

Ectopic Expression of Human .

Avicenna journal of medical biotechnology

Maryam Khaleghizadeh, Mohammad Mahdi Forghanifard, Abolfazl Rad, Moein Farshchian, Zahra Hejazi, Mehran Gholamin, Bahram Memar, Mohammad Reza Abbaszadegan

Affiliations

  1. Department of Microbiology, Damghan Branch, Islamic Azad University, Damghan, Iran.
  2. Human Genetic Division, Immunology Research Center, Avicenna Research Institute, Mashhad University of Medical Sciences, Mashhad, Iran.
  3. Department of Biology, Damghan Branch, Islamic Azad University, Damghan, Iran.
  4. Cellular and Molecular Research Center, Sabzevar University of Medical Sciences, Sabzevar, Iran.
  5. Department of Pathology, Imam Reza Hospital, Mashhad University of Medical Sciences, Mashhad, Iran.
  6. Medical Genetics Research Center, Faculty of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran.

PMID: 29849983 PMCID: PMC5960063

Abstract

BACKGROUND: Cancer/Testis Antigens (CTAs) are a sub-group of tumor-associated antigens which are expressed normally in germ line cells and trophoblast, and aberrantly in a variety of malignancies. One of the most important CTAs is Developmental Pluripotency Associated-2(DPPA2) with unknown biological function. Considering the importance of

METHODS: In this study, the coding sequence of

RESULTS: According to the critical characteristics of retroviral expression system such as stable and long time expression of interested gene and also being safe due to deletion of retroviral pathogenic genes, this system was used to induce expression of

CONCLUSION: Such strategies can be used to produce high levels of desired protein in target cells as a therapeutic target. The produced recombinant cells may present a valuable platform to analyze the effect of

Keywords: Carcinogenesis; Esophageal squamous cell carcinoma; Germ cells; Testis

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