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Chen CF, Lin MH, Chu KA, et al. Effective cardiac radiotherapy relieved life-threatening heart failure caused by advanced small cell lung cancer with cardiac metastasis: a case report. J Thorac Dis. 2018;10(4):E250-E254doi: 10.21037/jtd.2018.03.104.
Chen, C. F., Lin, M. H., Chu, K. A., Liu, W. S., Hsiao, S. H., & Lai, R. S. (2018). Effective cardiac radiotherapy relieved life-threatening heart failure caused by advanced small cell lung cancer with cardiac metastasis: a case report. Journal of thoracic disease, 10(4), E250-E254. https://doi.org/10.21037/jtd.2018.03.104
Chen, Chiu-Fan, et al. "Effective cardiac radiotherapy relieved life-threatening heart failure caused by advanced small cell lung cancer with cardiac metastasis: a case report." Journal of thoracic disease vol. 10,4 (2018): E250-E254. doi: https://doi.org/10.21037/jtd.2018.03.104
Chen CF, Lin MH, Chu KA, Liu WS, Hsiao SH, Lai RS. Effective cardiac radiotherapy relieved life-threatening heart failure caused by advanced small cell lung cancer with cardiac metastasis: a case report. J Thorac Dis. 2018 Apr;10(4):E250-E254. doi: 10.21037/jtd.2018.03.104. PMID: 29850163; PMCID: PMC5949501.
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J Thorac Dis. 2018 Apr;10(4):E250-E254. doi: 10.21037/jtd.2018.03.104.

Effective cardiac radiotherapy relieved life-threatening heart failure caused by advanced small cell lung cancer with cardiac metastasis: a case report.

Journal of thoracic disease

Chiu-Fan Chen, Min-Hsi Lin, Kuo-An Chu, Wen-Shan Liu, Shih-Hung Hsiao, Ruay-Sheng Lai

Affiliations

  1. Division of Chest Medicine, Department of Internal Medicine, Kaohsiung Veterans General Hospital, Kaohsiung.
  2. Department of Internal Medicine, Taipei Veterans General Hospital, Taitung Branch, Taitung.
  3. Department of Radiation Oncology, Kaohsiung Veterans General Hospital, Kaohsiung.
  4. Division of Cardiology, Department of Internal Medicine, Kaohsiung Veterans General Hospital, Kaohsiung.

PMID: 29850163 PMCID: PMC5949501 DOI: 10.21037/jtd.2018.03.104

Abstract

Cardiac radiotherapy is rarely used in clinical practice because of concern of adverse effects on the heart. We present a case of a 64-year-old man with advanced small cell lung cancer (SCLC) treated with chemo-radiotherapy who attained partial remission initially but had disease progression to bulky cardiac metastasis and significant pericardial effusion. Severe heart failure with hepatic failure was found. Chemotherapy and pericardiocentesis were contraindicated because of the associated high risk and bleeding tendency. Emergent palliative cardiac radiotherapy resulted in rapid improvements of dyspnea, liver function, and urine output. Pericardiocentesis was performed 5 days later and effusion cytology confirmed metastatic SCLC. To our knowledge, this is the first case of effective cardiac radiotherapy for SCLC with life-threatening cardiac metastasis. Palliative cardiac radiotherapy may be an effective alternative treatment for radiosensitive malignancy with cardiac metastasis in cases of multiple organ dysfunction and unsuitability for chemotherapy and pericardiocentesis.

Keywords: Cardiac tumor; pericardial effusion; radiotherapy; small cell lung cancer (SCLC)

Conflict of interest statement

Conflicts of Interest: The authors have no conflicts of interest to declare.

References

  1. BMJ Case Rep. 2012 Jul 19;2012:null - PubMed
  2. Radiat Oncol. 2011 Feb 14;6:16 - PubMed
  3. J Clin Oncol. 2008 Feb 20;26(6):1010-1 - PubMed
  4. J Clin Oncol. 2012 Sep 10;30(26):e260-3 - PubMed
  5. J Thorac Oncol. 2011 Apr;6(4):834-5 - PubMed
  6. Heart. 2009 Mar;95(3):252-8 - PubMed
  7. Cancer Med. 2016 Jun;5(6):989-96 - PubMed
  8. N Engl J Med. 2017 Dec 14;377(24):2325-2336 - PubMed
  9. Oncology (Williston Park). 2010 Jun;24(7):650-3 - PubMed
  10. Gynecol Oncol. 1998 Jun;69(3):264-8 - PubMed
  11. Int J Clin Oncol. 2008 Aug;13(4):369-72 - PubMed
  12. Ann Oncol. 2004 Mar;15(3):375-81 - PubMed
  13. Cancer. 2011 Feb 1;117(3):581-9 - PubMed
  14. Jpn J Clin Oncol. 2011 Apr;41(4):514-8 - PubMed
  15. Angiology. 2008 Jun-Jul;59(3):368-71 - PubMed
  16. J Clin Oncol. 2017 May 1;35(13):1387-1394 - PubMed
  17. J Clin Oncol. 2017 May 1;35(13):1395-1402 - PubMed

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