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Stafiej J, Kaźmierczak K, Linkowska K, et al. Evaluation of TGF-Beta 2 and VEGF. J Ophthalmol. 2018;2018:8293452doi: 10.1155/2018/8293452.
Stafiej, J., Kaźmierczak, K., Linkowska, K., Żuchowski, P., Grzybowski, T., & Malukiewicz, G. (2018). Evaluation of TGF-Beta 2 and VEGF. Journal of ophthalmology, 20188293452. https://doi.org/10.1155/2018/8293452
Stafiej, Joanna, et al. "Evaluation of TGF-Beta 2 and VEGF." Journal of ophthalmology vol. 2018 (2018): 8293452. doi: https://doi.org/10.1155/2018/8293452
Stafiej J, Kaźmierczak K, Linkowska K, Żuchowski P, Grzybowski T, Malukiewicz G. Evaluation of TGF-Beta 2 and VEGF. J Ophthalmol. 2018 Apr 23;2018:8293452. doi: 10.1155/2018/8293452. eCollection 2018. PMID: 29850215; PMCID: PMC5937441.
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J Ophthalmol. 2018 Apr 23;2018:8293452. doi: 10.1155/2018/8293452. eCollection 2018.

Evaluation of TGF-Beta 2 and VEGF.

Journal of ophthalmology

Joanna Stafiej, Karolina Kaźmierczak, Katarzyna Linkowska, Paweł Żuchowski, Tomasz Grzybowski, Grażyna Malukiewicz

Affiliations

  1. Department of Ophthalmology, Faculty of Medicine, Nicolaus Copernicus University in Toru?, Collegium Medicum in Bydgoszcz, Sklodowskiej-Curie 9, 85-094 Bydgoszcz, Poland.
  2. Department of Molecular and Forensic Genetics, Institute of Forensic Medicine, Faculty of Medicine, Nicolaus Copernicus University in Toru?, Collegium Medicum in Bydgoszcz, Sklodowskiej-Curie 9, 85-094 Bydgoszcz, Poland.
  3. Clinic of Rheumatology and Connective Tissue Diseases, J. Biziel University Hospital No. 2, Bydgoszcz, Poland.

PMID: 29850215 PMCID: PMC5937441 DOI: 10.1155/2018/8293452

Abstract

PURPOSE: To evaluate the expression profiles of the VEGF

METHODS: In this nonrandomized prospective study, 75 patients (34 females and 41 males) referred to pars plana vitrectomy (PPV) due to different retinal diseases were enrolled to the study. The samples of ERMs and ILMs collected during PPV were immediately put in TRIzol® Reagent (Life Technologies, USA) and stored at -70°C until RNA extraction. Gene expression analysis was done with TaqMan® Gene Expression Assays (Applied Biosystems, USA) following the manufacturer's instructions.

RESULTS: The gene expression levels of VEGF

CONCLUSIONS: Our results revealed that factors associated with angiogenesis and wound healing processes in eyes with RRD, PDR, iERM, and MH were more upregulated in ERMs than in ILMs. This may indicate that ILM is not responsible for reproliferation and its peeling should be avoided in routine PPV.

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