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Zhang N, Liu HX, Kang DM, et al. [Lead time bias and its control in observational studies for clinical outcomes]. Zhonghua Liu Xing Bing Xue Za Zhi. 2018;39(5):700-703doi: 10.3760/cma.j.issn.0254-6450.2018.05.032.
Zhang, N., Liu, H. X., Kang, D. M., & Wang, N. (2018). [Lead time bias and its control in observational studies for clinical outcomes]. Zhonghua liu xing bing xue za zhi = Zhonghua liuxingbingxue zazhi, 39(5), 700-703. https://doi.org/10.3760/cma.j.issn.0254-6450.2018.05.032
Zhang, N, et al. "[Lead time bias and its control in observational studies for clinical outcomes]." Zhonghua liu xing bing xue za zhi = Zhonghua liuxingbingxue zazhi vol. 39,5 (2018): 700-703. doi: https://doi.org/10.3760/cma.j.issn.0254-6450.2018.05.032
Zhang N, Liu HX, Kang DM, Wang N. [Lead time bias and its control in observational studies for clinical outcomes]. Zhonghua Liu Xing Bing Xue Za Zhi. 2018 May 10;39(5):700-703. doi: 10.3760/cma.j.issn.0254-6450.2018.05.032. Chinese. PMID: 29860822.
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Zhonghua Liu Xing Bing Xue Za Zhi. 2018 May 10;39(5):700-703. doi: 10.3760/cma.j.issn.0254-6450.2018.05.032.

[Lead time bias and its control in observational studies for clinical outcomes].

Zhonghua liu xing bing xue za zhi = Zhonghua liuxingbingxue zazhi

[Article in Chinese]
N Zhang, H X Liu, D M Kang, N Wang

Affiliations

  1. National Center for AIDS/STD Control and Prevention, Chinese Center for Disease Control and Prevention, Beijing 102206, China; Institute for AIDS Control and Prevention, Shandong Provincial Center for Disease Control and Prevention, Jinan 250014, China.
  2. Peking University People's Hospital, Beijing 100044, China.
  3. Institute for AIDS Control and Prevention, Shandong Provincial Center for Disease Control and Prevention, Jinan 250014, China.
  4. National Center for AIDS/STD Control and Prevention, Chinese Center for Disease Control and Prevention, Beijing 102206, China.

PMID: 29860822 DOI: 10.3760/cma.j.issn.0254-6450.2018.05.032

Abstract

Lead time bias might exist in observational study for clinical outcomes. This paper summarizes the concept of lead time bias, causes and control of lead time bias by using the studies of influences of screening diagnostic test on cancer patients'survival and highly active antiretroviral therapy on HIV/AIDS patients' survival as examples for the purpose of providing thinking and methods in the control of lead time bias for the accurate evaluation of the effects of interventions, such as test and treatment, on the diseases with multi courses or phases.

Keywords: Clinical outcome; Control; Highly active antiretroviral therapy; Lead time bias; Observational study

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