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Comput Stat Data Anal. 2018 Jun;122:101-114. doi: 10.1016/j.csda.2018.01.009.

A joint design for functional data with application to scheduling ultrasound scans.

Computational statistics & data analysis

So Young Park, Luo Xiao, Jayson D Willbur, Ana-Maria Staicu, N L'ntshotsholé Jumbe

Affiliations

  1. Eli Lilly and Company, Indianapolis, IN, USA.
  2. North Carolina State University, Raleigh, NC, USA.
  3. Metrum Research Group LLC, Tariffville, CT, USA.
  4. Bill & Melinda Gates Foundation, Seattle, WA, USA.

PMID: 29861518 PMCID: PMC5840761 DOI: 10.1016/j.csda.2018.01.009

Abstract

A joint design for sampling functional data is proposed to achieve optimal prediction of both functional data and a scalar outcome. The motivating application is fetal growth, where the objective is to determine the optimal times to collect ultrasound measurements in order to recover fetal growth trajectories and to predict child birth outcomes. The joint design is formulated using an optimization criterion and implemented in a pilot study. Performance of the proposed design is evaluated via simulation study and application to fetal ultrasound data.

Keywords: Covariance function; Fetal growth; Functional data analysis; Longitudinal data; Prediction

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