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Goltz A, Janowitz D, Hannemann A, et al. Association of Brain-Derived Neurotrophic Factor and Vitamin D with Depression and Obesity: A Population-Based Study. Neuropsychobiology. 2018;76(4):171-181doi: 10.1159/000489864.
Goltz, A., Janowitz, D., Hannemann, A., Nauck, M., Hoffmann, J., Seyfart, T., Völzke, H., Terock, J., & Grabe, H. J. (2017). Association of Brain-Derived Neurotrophic Factor and Vitamin D with Depression and Obesity: A Population-Based Study. Neuropsychobiology, 76(4), 171-181. https://doi.org/10.1159/000489864
Goltz, Annemarie, et al. "Association of Brain-Derived Neurotrophic Factor and Vitamin D with Depression and Obesity: A Population-Based Study." Neuropsychobiology vol. 76,4 (2017): 171-181. doi: https://doi.org/10.1159/000489864
Goltz A, Janowitz D, Hannemann A, Nauck M, Hoffmann J, Seyfart T, Völzke H, Terock J, Grabe HJ. Association of Brain-Derived Neurotrophic Factor and Vitamin D with Depression and Obesity: A Population-Based Study. Neuropsychobiology. 2017;76(4):171-181. doi: 10.1159/000489864. Epub 2018 Jun 19. PMID: 29920493.
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Neuropsychobiology. 2017;76(4):171-181. doi: 10.1159/000489864. Epub 2018 Jun 19.

Association of Brain-Derived Neurotrophic Factor and Vitamin D with Depression and Obesity: A Population-Based Study.

Neuropsychobiology

Annemarie Goltz, Deborah Janowitz, Anke Hannemann, Matthias Nauck, Johanna Hoffmann, Tom Seyfart, Henry Völzke, Jan Terock, Hans Jörgen Grabe

Affiliations

  1. Department of Psychiatry and Psychotherapy, University Medicine Greifswald, Greifswald, Germany.
  2. Institute of Clinical Chemistry and Laboratory Medicine, University Medicine Greifswald, Greifswald, Germany.
  3. DZHK (German Centre for Cardiovascular Research), Partner Site Greifswald, Greifswald, Germany.
  4. Institute for Community Medicine, University Medicine Greifswald, Greifswald, Germany.
  5. DZD (German Centre for Diabetes Research), Site Greifswald, Greifswald, Germany.
  6. Department of Psychiatry and Psychotherapy, University Medicine Greifswald, HELIOS Hospital Stralsund, Stralsund, Germany.
  7. German Center for Neurodegenerative Diseases (DZNE), Site Rostock/Greifswald, Rostock/Greifswald, Germany.

PMID: 29920493 DOI: 10.1159/000489864

Abstract

BACKGROUND: Depression and obesity are widespread and closely linked. Brain-derived neurotrophic factor (BDNF) and vitamin D are both assumed to be associated with depression and obesity. Little is known about the interplay between vitamin D and BDNF. We explored the putative associations and interactions between serum BDNF and vitamin D levels with depressive symptoms and abdominal obesity in a large population-based cohort.

METHODS: Data were obtained from the population-based Study of Health in Pomerania (SHIP)-Trend (n = 3,926). The associations of serum BDNF and vitamin D levels with depressive symptoms (measured using the Patient Health Questionnaire) were assessed with binary and multinomial logistic regression models. The associations of serum BDNF and vitamin D levels with obesity (measured by the waist-to-hip ratio [WHR]) were assessed with binary logistic and linear regression models with restricted cubic splines.

RESULTS: Logistic regression models revealed inverse associations of vitamin D with depression (OR = 0.966; 95% CI 0.951-0.981) and obesity (OR = 0.976; 95% CI 0.967-0.985). No linear association of serum BDNF with depression or obesity was found. However, linear regression models revealed a U-shaped association of BDNF with WHR (p < 0.001).

CONCLUSION: Vitamin D was inversely associated with depression and obesity. BDNF was associated with abdominal obesity, but not with depression. At the population level, our results support the relevant roles of vitamin D and BDNF in mental and physical health-related outcomes.

© 2018 S. Karger AG, Basel.

Keywords: Brain-derived neurotrophic factor; Depression; Obesity; Vitamin D

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