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Karthikeyan A, Gupta N, Tang C, et al. Microglial SMAD4 regulated by microRNA-146a promotes migration of microglia which support tumor progression in a glioma environment. Oncotarget. 2018;9(38):24950-24969doi: 10.18632/oncotarget.25116.
Karthikeyan, A., Gupta, N., Tang, C., Mallilankaraman, K., Silambarasan, M., Shi, M., Lu, L., Ang, B. T., Ling, E. A., & Dheen, S. T. (2018). Microglial SMAD4 regulated by microRNA-146a promotes migration of microglia which support tumor progression in a glioma environment. Oncotarget, 9(38), 24950-24969. https://doi.org/10.18632/oncotarget.25116
Karthikeyan, Aparna, et al. "Microglial SMAD4 regulated by microRNA-146a promotes migration of microglia which support tumor progression in a glioma environment." Oncotarget vol. 9,38 (2018): 24950-24969. doi: https://doi.org/10.18632/oncotarget.25116
Karthikeyan A, Gupta N, Tang C, Mallilankaraman K, Silambarasan M, Shi M, Lu L, Ang BT, Ling EA, Dheen ST. Microglial SMAD4 regulated by microRNA-146a promotes migration of microglia which support tumor progression in a glioma environment. Oncotarget. 2018 May 18;9(38):24950-24969. doi: 10.18632/oncotarget.25116. eCollection 2018 May 18. PMID: 29861845; PMCID: PMC5982777.
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Oncotarget. 2018 May 18;9(38):24950-24969. doi: 10.18632/oncotarget.25116. eCollection 2018 May 18.

Microglial SMAD4 regulated by microRNA-146a promotes migration of microglia which support tumor progression in a glioma environment.

Oncotarget

Aparna Karthikeyan, Neelima Gupta, Carol Tang, Karthik Mallilankaraman, Maskomani Silambarasan, Meng Shi, Lei Lu, Beng Ti Ang, Eng-Ang Ling, S Thameem Dheen

Affiliations

  1. Department of Anatomy, Yong Loo Lin School of Medicine, National University of Singapore, Singapore.
  2. Department of Research, National Neuroscience Institute, Singapore.
  3. Duke-NUS Medical School, Singapore.
  4. Division of Cellular and Molecular Research, National Cancer Centre, Singapore.
  5. Department of Physiology, Yong Loo Lin School of Medicine, National University of Singapore, Singapore.
  6. School of Biological Sciences, Nanyang Technological University, Singapore.
  7. Department of Neurosurgery, National Neuroscience Institute, Singapore.
  8. Singapore Institute for Clinical Sciences, ASTAR, Singapore.

PMID: 29861845 PMCID: PMC5982777 DOI: 10.18632/oncotarget.25116

Abstract

Glioma tumors constitute a significant portion of microglial cells, which are known to support tumor progression. The present study demonstrates that transforming growth factor-β (TGFβ) signaling pathway in microglia in a glioma environment is involved in tumor progression and pathogenesis. It has been shown that the TGFβ level is elevated in higher grades of gliomas and its signaling pathway regulates tumor progression through phosphorylation of SMAD2 and SMAD3, which form a complex with SMAD4 to regulate target gene transcription. In an

Keywords: SMAD4; TGFβ; glioma; microRNA-146a; microglia

Conflict of interest statement

CONFLICTS OF INTEREST The authors declare no conflicts of interest.

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