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Kapahtia S, Hazam RK, Asim M, et al. Role of Glutathione S Transferase M1 and T1 Gene Polymorphism in Hepatitis B Related Liver Diseases and Cryptogenic Cirrhosis. J Clin Exp Hepatol. 2017;8(2):169-172doi: 10.1016/j.jceh.2017.05.208.
Kapahtia, S., Hazam, R. K., Asim, M., Karra, V. K., Chowdhury, S. J., Das, B. C., & Kar, P. (2018). Role of Glutathione S Transferase M1 and T1 Gene Polymorphism in Hepatitis B Related Liver Diseases and Cryptogenic Cirrhosis. Journal of clinical and experimental hepatology, 8(2), 169-172. https://doi.org/10.1016/j.jceh.2017.05.208
Kapahtia, Siddharth, et al. "Role of Glutathione S Transferase M1 and T1 Gene Polymorphism in Hepatitis B Related Liver Diseases and Cryptogenic Cirrhosis." Journal of clinical and experimental hepatology vol. 8,2 (2018): 169-172. doi: https://doi.org/10.1016/j.jceh.2017.05.208
Kapahtia S, Hazam RK, Asim M, Karra VK, Chowdhury SJ, Das BC, Kar P. Role of Glutathione S Transferase M1 and T1 Gene Polymorphism in Hepatitis B Related Liver Diseases and Cryptogenic Cirrhosis. J Clin Exp Hepatol. 2018 Jun;8(2):169-172. doi: 10.1016/j.jceh.2017.05.208. Epub 2017 May 31. PMID: 29892180; PMCID: PMC5992258.
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J Clin Exp Hepatol. 2018 Jun;8(2):169-172. doi: 10.1016/j.jceh.2017.05.208. Epub 2017 May 31.

Role of Glutathione S Transferase M1 and T1 Gene Polymorphism in Hepatitis B Related Liver Diseases and Cryptogenic Cirrhosis.

Journal of clinical and experimental hepatology

Siddharth Kapahtia, Rajib K Hazam, Mohammad Asim, Vijay K Karra, Soumya J Chowdhury, Bhudev C Das, Premashis Kar

Affiliations

  1. Department of Medicine, Maulana Azad Medical College, University of Delhi, India.
  2. Dr B.R.Ambedkar Center for Biomedical Research, University of Delhi, India.

PMID: 29892180 PMCID: PMC5992258 DOI: 10.1016/j.jceh.2017.05.208

Abstract

BACKGROUND AND AIM: Progression of hepatitis B virus infection (HBV) might be affected by host genetic factors. The present study was undertaken to study the role of glutathione S-transferases (GST)-M1 and T1 gene polymorphisms in different stages of HBV infection: HBV inactive carrier, chronic hepatitis B and cirrhosis, and cryptogenic cirrhosis.

METHODS: The study population comprised of 170 subjects; 120 cases (HBV inactive carrier,

RESULTS: The GSTM1 null genotype was seen more commonly in hepatitis B cirrhosis (

CONCLUSION: The patients with GSTM1 null genotype are at risk of progression of liver disease as the frequency of GSTM1 null genotype was found to be significantly higher in chronic hepatitis B, hepatitis B cirrhosis and cryptogenic cirrhosis as compared with controls.

Keywords: ALT, alanine aminotransferase; AST, aspartate aminotransferase; GST, glutathione S-transferase; GSTM1; GSTT1; HBV, hepatitis B virus; cryptogenic cirrhosis; hepatitis B; null genotype

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