Display options
Cite
Sokhadze EM, Lamina EV, Casanova EL, et al. Exploratory Study of rTMS Neuromodulation Effects on Electrocortical Functional Measures of Performance in an Oddball Test and Behavioral Symptoms in Autism. Front Syst Neurosci. 2018;12:20doi: 10.3389/fnsys.2018.00020.
Sokhadze, E. M., Lamina, E. V., Casanova, E. L., Kelly, D. P., Opris, I., Tasman, A., & Casanova, M. F. (2018). Exploratory Study of rTMS Neuromodulation Effects on Electrocortical Functional Measures of Performance in an Oddball Test and Behavioral Symptoms in Autism. Frontiers in systems neuroscience, 1220. https://doi.org/10.3389/fnsys.2018.00020
Sokhadze, Estate M, et al. "Exploratory Study of rTMS Neuromodulation Effects on Electrocortical Functional Measures of Performance in an Oddball Test and Behavioral Symptoms in Autism." Frontiers in systems neuroscience vol. 12 (2018): 20. doi: https://doi.org/10.3389/fnsys.2018.00020
Sokhadze EM, Lamina EV, Casanova EL, Kelly DP, Opris I, Tasman A, Casanova MF. Exploratory Study of rTMS Neuromodulation Effects on Electrocortical Functional Measures of Performance in an Oddball Test and Behavioral Symptoms in Autism. Front Syst Neurosci. 2018 May 28;12:20. doi: 10.3389/fnsys.2018.00020. eCollection 2018. PMID: 29892214; PMCID: PMC5985329.
Copy Download .nbib Format: NLM
Share it on

Front Syst Neurosci. 2018 May 28;12:20. doi: 10.3389/fnsys.2018.00020. eCollection 2018.

Exploratory Study of rTMS Neuromodulation Effects on Electrocortical Functional Measures of Performance in an Oddball Test and Behavioral Symptoms in Autism.

Frontiers in systems neuroscience

Estate M Sokhadze, Eva V Lamina, Emily L Casanova, Desmond P Kelly, Ioan Opris, Allan Tasman, Manuel F Casanova

Affiliations

  1. Department of Biomedical Sciences, School of Medicine Greenville, University of South Carolina, Greenville, SC, United States.
  2. Department of Psychiatry and Behavioral Sciences, University of Louisville, Louisville, KY, United States.
  3. Department of Pediatrics, Greenville Health System, Greenville, SC, United States.
  4. Miller School of Medicine, University of Miami, Miami, FL, United States.

PMID: 29892214 PMCID: PMC5985329 DOI: 10.3389/fnsys.2018.00020

Abstract

There is no accepted pathology to autism spectrum disorders (ASD) but research suggests the presence of an altered excitatory/inhibitory (E/I) bias in the cerebral cortex. Repetitive transcranial magnetic stimulation (rTMS) offers a non-invasive means of modulating the E/I cortical bias with little in terms of side effects. In this study, 124 high functioning ASD children (IQ > 80, <18 years of age) were recruited and assigned using randomization to either a waitlist group or one of three different number of weekly rTMS sessions (i.e., 6, 12, and 18). TMS consisted of trains of 1.0 Hz frequency pulses applied over the dorsolateral prefrontal cortex (DLPFC). The experimental task was a visual oddball with illusory Kanizsa figures. Behavioral response variables included reaction time and error rate along with such neurophysiological indices such as stimulus and response-locked event-related potentials (ERP). One hundred and twelve patients completed the assigned number of TMS sessions. Results showed significant changes from baseline to posttest period in the following measures: motor responses accuracy [lower percentage of committed errors, slower latency of commission errors and restored normative post-error reaction time slowing in both early and later-stage ERP indices, enhanced magnitude of error-related negativity (ERN), improved error monitoring and post-error correction functions]. In addition, screening surveys showed significant reductions in aberrant behavior ratings and in both repetitive and stereotypic behaviors. These differences increased with the total number of treatment sessions. Our results suggest that rTMS, particularly after 18 sessions, facilitates cognitive control, attention and target stimuli recognition by improving discrimination between task-relevant and task-irrelevant illusory figures in an oddball test. The noted improvement in executive functions of behavioral performance monitoring further suggests that TMS has the potential to target core features of ASD.

Keywords: ERP; TMS; aberrant and repetitive behaviors; autism spectrum disorder; executive functions; oddball task; reaction time

References

  1. J Neurother. 2012;16(1):12-31 - PubMed
  2. World J Biol Psychiatry. 2016 Apr;17 (3):174-86 - PubMed
  3. Cognition. 1994 Apr-Jun;50(1-3):115-32 - PubMed
  4. Neuropsychologia. 2007 Apr 9;45(8):1707-14 - PubMed
  5. Acta Neuropathol Commun. 2013 Oct 11;1:67 - PubMed
  6. Eur J Neurosci. 2008 Jul;28(2):399-406 - PubMed
  7. Science. 1998 May 1;280(5364):747-9 - PubMed
  8. Front Synaptic Neurosci. 2010 Jun 28;2:26 - PubMed
  9. Brain Res Cogn Brain Res. 2001 Mar;11(1):127-45 - PubMed
  10. J Child Adolesc Psychopharmacol. 2001 Spring;11(1):69-75 - PubMed
  11. Front Neurosci. 2017 May 09;11:255 - PubMed
  12. Biol Psychol. 2007 Apr;75(1):45-51 - PubMed
  13. Neuroscientist. 2003 Dec;9(6):496-507 - PubMed
  14. Arch Gen Psychiatry. 1999 Apr;56(4):300-11 - PubMed
  15. Brain Stimul. 2015 Jan-Feb;8(1):76-87 - PubMed
  16. Brain Stimul. 2014 Mar-Apr;7(2):206-11 - PubMed
  17. Dev Neuropsychol. 2004;25(3):355-76 - PubMed
  18. Cortex. 2009 Oct;45(9):1025-34 - PubMed
  19. Electroencephalogr Clin Neurophysiol. 1994 Oct;93(5):358-71 - PubMed
  20. Curr Opin Neurobiol. 2000 Apr;10(2):232-7 - PubMed
  21. Biol Psychol. 2000 Jan;51(2-3):87-107 - PubMed
  22. J Affect Disord. 2005 Nov;88(3):255-67 - PubMed
  23. Clin Neurophysiol. 2007 Oct;118(10):2128-48 - PubMed
  24. Br J Disord Commun. 1989 Aug;24(2):199-200 - PubMed
  25. J Int Neuropsychol Soc. 1997 Jul;3(4):303-16 - PubMed
  26. Acta Neuropathol. 2006 Sep;112(3):287-303 - PubMed
  27. J Child Neurol. 2002 Sep;17(9):692-5 - PubMed
  28. J ECT. 2005 Jun;21(2):88-95 - PubMed
  29. Int Rev Psychiatry. 2011 Oct;23(5):445-53 - PubMed
  30. Am J Psychiatry. 2003 May;160(5):835-45 - PubMed
  31. Am J Psychiatry. 2002 Jul;159(7):1093-102 - PubMed
  32. Clin Neurophysiol. 2009 Dec;120(12):2008-39 - PubMed
  33. Transl Neurosci. 2012 Jun 1;3(2):170-180 - PubMed
  34. Science. 2004 Oct 15;306(5695):443-7 - PubMed
  35. Sci Am. 1976 Apr;234(4):48-52 - PubMed
  36. J Cogn Neurosci. 2002 May 15;14(4):593-602 - PubMed
  37. Acta Paediatr. 2015 Apr;104(4):346-55 - PubMed
  38. J Neurol Neurosurg Psychiatry. 2004 Jul;75(7):945-8 - PubMed
  39. J Child Psychol Psychiatry. 1991 Nov;32(7):1081-105 - PubMed
  40. J Clin Neurosci. 2013 Feb;20(2):257-62 - PubMed
  41. Genes Brain Behav. 2003 Oct;2(5):255-67 - PubMed
  42. Front Hum Neurosci. 2015 Feb 04;9:29 - PubMed
  43. Brain. 2004 Aug;127(Pt 8):1811-21 - PubMed
  44. Brain Pathol. 2007 Oct;17(4):422-33 - PubMed
  45. Clin Neurophysiol. 2004 Aug;115(8):1730-9 - PubMed
  46. Brain Res Cogn Brain Res. 2003 Oct;17(3):651-64 - PubMed
  47. J Autism Dev Disord. 2009 Apr;39(4):619-34 - PubMed
  48. J Clin Neurophysiol. 1992 Oct;9(4):456-79 - PubMed
  49. J Neurother. 2010 Apr 1;14(2):79-95 - PubMed
  50. Neuropsychologia. 2006;44(11):2017-36 - PubMed
  51. Psychophysiology. 2001 Sep;38(5):752-60 - PubMed
  52. Front Hum Neurosci. 2015 Oct 02;9:544 - PubMed
  53. Appl Psychophysiol Biofeedback. 2009 Mar;34(1):37-51 - PubMed
  54. Appl Psychophysiol Biofeedback. 2012 Jun;37(2):91-102 - PubMed
  55. Psychophysiology. 2011 Jan;48(1):55-63 - PubMed
  56. Semin Pediatr Neurol. 2004 Sep;11(3):225-8 - PubMed
  57. Biol Psychiatry. 1999 Sep 15;46(6):781-9 - PubMed
  58. Clin Neurophysiol. 2001 Aug;112(8):1367-77 - PubMed
  59. Front Syst Neurosci. 2014 Aug 06;8:134 - PubMed
  60. Brain Stimul. 2015 Sep-Oct;8(5):965-73 - PubMed
  61. Nat Neurosci. 2000 May;3(5):516-20 - PubMed
  62. Appl Psychophysiol Biofeedback. 2014 Dec;39(3-4):237-57 - PubMed
  63. Nat Neurosci. 2006 Jan;9(1):28-30 - PubMed
  64. J Autism Dev Disord. 2015 Feb;45(2):524-36 - PubMed
  65. Electroencephalogr Clin Neurophysiol. 1994 May;92(3):225-37 - PubMed
  66. J Autism Dev Disord. 2000 Jun;30(3):237-43 - PubMed
  67. J Child Neurol. 2002 Feb;17(2):142-5 - PubMed
  68. Brain Cogn. 2006 Jun;61(1):96-109 - PubMed
  69. Clin Neurophysiol. 2008 May;119(5):973-84 - PubMed
  70. J Autism Dev Disord. 1989 Mar;19(1):1-17 - PubMed
  71. Electroencephalogr Clin Neurophysiol. 1990 Mar;75(3):207-20 - PubMed
  72. Front Hum Neurosci. 2014 Oct 21;8:851 - PubMed
  73. Psychophysiology. 2009 Nov;46(6):1179-89 - PubMed
  74. Transl Neurosci. 2010 Jun;1(2):177-187 - PubMed
  75. Neurology. 2002 Feb 12;58(3):428-32 - PubMed
  76. J Neurother. 2010 Jul 1;14(3):179-194 - PubMed
  77. Brain. 2008 Sep;131(Pt 9):2464-78 - PubMed
  78. Front Neurosci. 2016 Aug 05;10:336 - PubMed
  79. Appl Psychophysiol Biofeedback. 2010 Jun;35(2):147-61 - PubMed
  80. Autism Res. 2016 Feb;9(2):184-203 - PubMed
  81. Ann Phys Rehabil Med. 2015 Sep;58(4):208-13 - PubMed
  82. J Neuropsychiatry Clin Neurosci. 2002 Fall;14(4):406-15 - PubMed
  83. Pharmacol Ther. 2012 Jan;133(1):98-107 - PubMed
  84. Eur J Paediatr Neurol. 2004;8(1):7-19 - PubMed
  85. J Clin Neurophysiol. 2001 Jul;18(4):302-17 - PubMed
  86. J Neurosci. 2004 Oct 20;24(42):9228-31 - PubMed
  87. Neurophysiol Clin. 2017 Feb;47(1):35-46 - PubMed
  88. Neuroimage. 2005 Dec;28(4):1007-13 - PubMed
  89. Rev Neurosci. 2004;15(4):253-66 - PubMed
  90. J Autism Dev Disord. 2009 Mar;39(3):495-510 - PubMed
  91. CNS Spectr. 2003 Jul;8(7):496-514 - PubMed
  92. Appl Psychophysiol Biofeedback. 2016 Mar;41(1):47-60 - PubMed
  93. Clin Neurophysiol. 2000 May;111(5):800-5 - PubMed

Publication Types

Grant support