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Yin JQ, Fu YW, Xie XB, et al. Telangiectatic osteosarcoma: Outcome analyses and a diagnostic model for differentiation from aneurysmal bone cyst. J Bone Oncol. 2017;11:10-16doi: 10.1016/j.jbo.2017.11.003.
Yin, J. Q., Fu, Y. W., Xie, X. B., Cheng, X. Y., Yang, X. Y., Liu, W. H., Tu, J., Gao, Z. H., & Shen, J. N. (2018). Telangiectatic osteosarcoma: Outcome analyses and a diagnostic model for differentiation from aneurysmal bone cyst. Journal of bone oncology, 1110-16. https://doi.org/10.1016/j.jbo.2017.11.003
Yin, Jun-Qiang, et al. "Telangiectatic osteosarcoma: Outcome analyses and a diagnostic model for differentiation from aneurysmal bone cyst." Journal of bone oncology vol. 11 (2018): 10-16. doi: https://doi.org/10.1016/j.jbo.2017.11.003
Yin JQ, Fu YW, Xie XB, Cheng XY, Yang XY, Liu WH, Tu J, Gao ZH, Shen JN. Telangiectatic osteosarcoma: Outcome analyses and a diagnostic model for differentiation from aneurysmal bone cyst. J Bone Oncol. 2017 Nov 26;11:10-16. doi: 10.1016/j.jbo.2017.11.003. eCollection 2018 Jun. PMID: 29892520; PMCID: PMC5993956.
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J Bone Oncol. 2017 Nov 26;11:10-16. doi: 10.1016/j.jbo.2017.11.003. eCollection 2018 Jun.

Telangiectatic osteosarcoma: Outcome analyses and a diagnostic model for differentiation from aneurysmal bone cyst.

Journal of bone oncology

Jun-Qiang Yin, Yi-Wei Fu, Xian-Biao Xie, Xiao-Yu Cheng, Xiao-Yu Yang, Wei-Hai Liu, Jian Tu, Zhen-Hua Gao, Jing-Nan Shen

Affiliations

  1. Department of Orthopedic Oncology, First Affiliated Hospital of Sun Yat-Sen University, 58 Second Zhongshan Road, Guangzhou, Guangdong, China.
  2. Zhongshan School of Medicine, Sun Yat-Sen University, 74 Second Zhongshan Road, Guangzhou, Guangdong, China.
  3. Department of Radiology, First Affiliated Hospital of Sun Yat-Sen University, 58 Second Zhongshan Road, Guangzhou, Guangdong, China.

PMID: 29892520 PMCID: PMC5993956 DOI: 10.1016/j.jbo.2017.11.003

Abstract

BACKGROUND AND PURPOSE: Telangiectatic osteosarcoma (TOS), a rare variant of osteosarcoma, may be easily misdiagnosed as aneurysmal bone cyst (ABC). The aims of this study were to investigate the diagnostic and prognostic factors of TOS by reviewing our experience with TOS and to develop a diagnostic model that may distinguish TOS from ABC.

MATERIALS AND METHODS: We identified 51 cases of TOS treated at the First Affiliated Hospital of Sun Yat-Sen University from March 2001 to January 2016 and reviewed their records, imaging information and pathological studies. A diagnostic model was developed to differentiate TOS and ABC by Bayes discriminant analysis and was evaluated. The log-rank test was used to analyze the prognostic factors of TOS and to compare the outcome differences between TOS and other high-grade osteosarcoma subtypes.

RESULTS: The multi-disciplinary diagnostic method employed that combined clinical, imaging, and pathological studies enhanced the diagnostic accuracy. Age 18 years or younger and pathologic fracture were more common among the TOS patients than among the ABC patients

CONCLUSIONS: The multi-disciplinary diagnostic method and diagnostic model based on predictive factors,

Keywords: ABC, Aneurysmal bone cyst; ALP, Alkaline phosphatase; Aneurysmal bone cyst; Diagnostic model; Discriminant analysis; EFS, Event-free survival; LDH, Lactate dehydrogenase; MR, Magnetic resonance; MTX, Methotrexate; OS, Osteosarcoma; Prognostic factor; SD, Standard deviations; TOS, Telangiectatic osteosarcoma; Telangiectatic osteosarcoma; WBC, White blood cell

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