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Ningrum VDA, Ikawati Z, Sadewa AH, et al. Patient-factors associated with metformin steady-state levels in type 2 diabetes mellitus with therapeutic dosage. J Clin Transl Endocrinol. 2018;12:42-47doi: 10.1016/j.jcte.2018.05.001.
Ningrum, V. D. A., Ikawati, Z., Sadewa, A. H., & Ikhsan, M. R. (2018). Patient-factors associated with metformin steady-state levels in type 2 diabetes mellitus with therapeutic dosage. Journal of clinical & translational endocrinology, 1242-47. https://doi.org/10.1016/j.jcte.2018.05.001
Ningrum, Vitarani D A, et al. "Patient-factors associated with metformin steady-state levels in type 2 diabetes mellitus with therapeutic dosage." Journal of clinical & translational endocrinology vol. 12 (2018): 42-47. doi: https://doi.org/10.1016/j.jcte.2018.05.001
Ningrum VDA, Ikawati Z, Sadewa AH, Ikhsan MR. Patient-factors associated with metformin steady-state levels in type 2 diabetes mellitus with therapeutic dosage. J Clin Transl Endocrinol. 2018 May 13;12:42-47. doi: 10.1016/j.jcte.2018.05.001. eCollection 2018 Jun. PMID: 29892566; PMCID: PMC5992324.
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J Clin Transl Endocrinol. 2018 May 13;12:42-47. doi: 10.1016/j.jcte.2018.05.001. eCollection 2018 Jun.

Patient-factors associated with metformin steady-state levels in type 2 diabetes mellitus with therapeutic dosage.

Journal of clinical & translational endocrinology

Vitarani D A Ningrum, Zullies Ikawati, Ahmad H Sadewa, Mohammad R Ikhsan

Affiliations

  1. Department of Pharmacy, Universitas Islam Indonesia, Yogyakarta 55584, Indonesia.
  2. Faculty of Pharmacy, Universitas Gadjah Mada, Yogyakarta 55281, Indonesia.
  3. Faculty of Medicine, Universitas Gadjah Mada, Yogyakarta 55281, Indonesia.
  4. Department of Internal Medicine, Dr. Sardjito General Hospital, Yogyakarta 55281, Indonesia.

PMID: 29892566 PMCID: PMC5992324 DOI: 10.1016/j.jcte.2018.05.001

Abstract

AIMS: This prospective study aimed to analyze metformin steady-state concentration in repeated constant dosage and the influencing patient-factors as well as to correlate them with glycemic control.

METHODS: The validated HPLC-UV method was used to examine metformin steady-state concentration, while FBG and glycated albumin were used as the parameters of glycemic control during metformin administration.

RESULTS: A total of 82 type-2 diabetes patients were involved with 32.1% of them having metformin Css

CONCLUSIONS: Along with initial hyperglycemia and eGFR, metformin Css

Keywords: Metformin; Patient-factors; Steady-state level; Therapeutic dosage; Type-2 diabetes mellitus

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