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Donadon M, Lleo A, Di Tommaso L, et al. The Shifting Paradigm of Prognostic Factors of Colorectal Liver Metastases: From Tumor-Centered to Host Immune-Centered Factors. Front Oncol. 2018;8:181doi: 10.3389/fonc.2018.00181.
Donadon, M., Lleo, A., Di Tommaso, L., Soldani, C., Franceschini, B., Roncalli, M., & Torzilli, G. (2018). The Shifting Paradigm of Prognostic Factors of Colorectal Liver Metastases: From Tumor-Centered to Host Immune-Centered Factors. Frontiers in oncology, 8181. https://doi.org/10.3389/fonc.2018.00181
Donadon, Matteo, et al. "The Shifting Paradigm of Prognostic Factors of Colorectal Liver Metastases: From Tumor-Centered to Host Immune-Centered Factors." Frontiers in oncology vol. 8 (2018): 181. doi: https://doi.org/10.3389/fonc.2018.00181
Donadon M, Lleo A, Di Tommaso L, Soldani C, Franceschini B, Roncalli M, Torzilli G. The Shifting Paradigm of Prognostic Factors of Colorectal Liver Metastases: From Tumor-Centered to Host Immune-Centered Factors. Front Oncol. 2018 May 28;8:181. doi: 10.3389/fonc.2018.00181. eCollection 2018. PMID: 29892573; PMCID: PMC5985314.
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Front Oncol. 2018 May 28;8:181. doi: 10.3389/fonc.2018.00181. eCollection 2018.

The Shifting Paradigm of Prognostic Factors of Colorectal Liver Metastases: From Tumor-Centered to Host Immune-Centered Factors.

Frontiers in oncology

Matteo Donadon, Ana Lleo, Luca Di Tommaso, Cristiana Soldani, Barbara Franceschini, Massimo Roncalli, Guido Torzilli

Affiliations

  1. Department of Hepatobiliary and General Surgery, Humanitas Clinical and Research Center, Rozzano, Italy.
  2. Department of Biomedical Science, Humanitas University, Rozzano, Italy.
  3. Department of Internal Medicine, Humanitas Clinical and Research Center, Rozzano, Italy.
  4. Department of Pathology, Humanitas Clinical and Research Center, Rozzano, Italy.

PMID: 29892573 PMCID: PMC5985314 DOI: 10.3389/fonc.2018.00181

Abstract

The determinants of prognosis in patients with colorectal liver metastases (CLM) have been traditionally searched among the tumoral factors, either of the primary colorectal tumor or of the CLM. While many different scoring systems have been developed based on those clinic-pathological factors with disparate results, there has been the introduction of genetic biological markers that added a theranostic perspective. More recently, other important elements, such as those factors related to the host immune system, have been proposed as determinants of prognosis of CLM patients. In the present work, we review the current prognostic factors of CLM patients as well as the burgeoning shifting paradigm of prognostication that relies on the host immune system.

Keywords: colorectal cancer; colorectal cancer liver metastases; colorectal liver metastases; host immune system; immune response; immunotherapy

References

  1. Nature. 2007 Dec 6;450(7171):903-7 - PubMed
  2. Carcinogenesis. 2004 Apr;25(4):527-33 - PubMed
  3. Cytokine. 2002 Nov 24;20(4):184-90 - PubMed
  4. J Clin Oncol. 1997 Mar;15(3):938-46 - PubMed
  5. Clin Cancer Res. 2007 Nov 1;13(21):6419-28 - PubMed
  6. Ann Surg Oncol. 2005 Nov;12(11):900-9 - PubMed
  7. Dis Colon Rectum. 1999 May;42(5):632-9 - PubMed
  8. Gut. 1979 Oct;20(10):868-74 - PubMed
  9. Lancet Oncol. 2008 Oct;9(10):962-72 - PubMed
  10. J Clin Oncol. 2009 Aug 1;27(22):3677-83 - PubMed
  11. J Gastrointest Surg. 2017 Aug;21(8):1226-1236 - PubMed
  12. Cancer Res. 1998 Aug 15;58(16):3491-4 - PubMed
  13. Ann Surg. 2007 Aug;246(2):295-300 - PubMed
  14. Ann Thorac Surg. 2004 Jul;78(1):238-44 - PubMed
  15. Br J Surg. 1990 Nov;77(11):1241-6 - PubMed
  16. Cancer Immunol Immunother. 2018 Mar 23;:null - PubMed
  17. Ann Surg Oncol. 2015;22(6):1908-14 - PubMed
  18. Ann Oncol. 2007 Jul;18(7):1190-5 - PubMed
  19. Cancer. 2009 Nov 1;115(21):4990-9 - PubMed
  20. HPB (Oxford). 2010 Feb;12(1):43-9 - PubMed
  21. Am J Surg. 1997 Jun;173(6):467-71 - PubMed
  22. Proc Natl Acad Sci U S A. 2016 Feb 16;113(7):E874-83 - PubMed
  23. J Clin Invest. 2015 Sep;125(9):3356-64 - PubMed
  24. J Pathol. 1999 Dec;189(4):487-95 - PubMed
  25. Dig Surg. 2013;30(4-6):293-301 - PubMed
  26. Cancer Res. 1999 Oct 15;59(20):5169-75 - PubMed
  27. HPB (Oxford). 2013 Oct;15(10):803-13 - PubMed
  28. Int Surg. 1993 Oct-Dec;78(4):288-91 - PubMed
  29. J Surg Oncol. 2012 Aug 1;106(2):123-9 - PubMed
  30. J Clin Oncol. 2011 Feb 20;29(6):610-8 - PubMed
  31. Am J Gastroenterol. 1999 Mar;94(3):739-43 - PubMed
  32. Ann Surg. 2008 Jan;247(1):125-35 - PubMed
  33. Chest. 1986 Jan;89(1):109-12 - PubMed
  34. Ann Surg. 2005 May;241(5):715-22, discussion 722-4 - PubMed
  35. Ann Surg. 1997 Nov;226(5):582-6 - PubMed
  36. Ann Surg Oncol. 2011 May;18(5):1380-8 - PubMed
  37. Lancet Oncol. 2009 Sep;10(9):877-84 - PubMed
  38. Recent Results Cancer Res. 2003;162:115-32 - PubMed
  39. Ann Surg Oncol. 2009 Sep;16(9):2524-30 - PubMed
  40. Ann Surg. 2013 Jun;257(6):1079-88 - PubMed
  41. Ann Surg. 2008 Oct;248(4):626-37 - PubMed
  42. Semin Oncol. 2006 Aug;33(4):369-85 - PubMed
  43. Hepatology. 1991 Sep;14(3):495-503 - PubMed
  44. Cell Prolif. 1998 Jun-Aug;31(3-4):139-53 - PubMed
  45. Ann Thorac Surg. 2000 Aug;70(2):380-3 - PubMed
  46. Arch Surg. 1995 Jan;130(1):9-14 - PubMed
  47. Science. 2011 Mar 25;331(6024):1565-70 - PubMed
  48. Cancer. 2004 Jan 15;100(2):270-8 - PubMed
  49. Cell. 2011 Mar 4;144(5):646-74 - PubMed
  50. Lancet. 2008 Mar 22;371(9617):1007-16 - PubMed
  51. Chest. 2001 Apr;119(4):1069-72 - PubMed
  52. Cancer Res. 2012 Aug 1;72(15):3735-43 - PubMed
  53. Eur J Surg Oncol. 2001 Feb;27(1):80-7 - PubMed
  54. Cancer Immunol Immunother. 1998 May;46(3):167-73 - PubMed
  55. Cell Mol Immunol. 2016 May;13(3):267-76 - PubMed
  56. J Autoimmun. 2016 Jan;66:40-50 - PubMed
  57. Ann Surg Oncol. 2013 Mar;20(3):946-55 - PubMed
  58. Hepatogastroenterology. 1997 May-Jun;44(15):751-9 - PubMed
  59. Ann Surg. 1987 Mar;205(3):256-63 - PubMed
  60. Arch Surg. 2004 Nov;139(11):1168-72 - PubMed
  61. World J Surg. 2001 May;25(5):638-44 - PubMed
  62. Br J Surg. 1993 Aug;80(8):1032-5 - PubMed
  63. Nat Immunol. 2013 Oct;14(10):1014-22 - PubMed
  64. J Am Coll Surg. 1995 Feb;180(2):213-9 - PubMed
  65. Science. 2006 Sep 29;313(5795):1960-4 - PubMed
  66. J Clin Oncol. 2012 Apr 20;30(12 ):1288-95 - PubMed
  67. Trends Immunol. 2016 Mar;37(3):208-220 - PubMed
  68. Immunity. 2016 Mar 15;44(3):698-711 - PubMed
  69. Am Surg. 1997 Jul;63(7):605-10 - PubMed
  70. J Am Coll Surg. 2005 Oct;201(4):517-28 - PubMed
  71. Int J Cancer. 2009 Jun 1;124(11):2589-96 - PubMed
  72. CA Cancer J Clin. 2013 Jan;63(1):11-30 - PubMed
  73. World J Surg. 2013 Nov;37(11):2647-54 - PubMed
  74. Oncologist. 2012;17 (10 ):1225-39 - PubMed
  75. Nat Rev Mol Cell Biol. 2001 Feb;2(2):127-37 - PubMed
  76. J Clin Oncol. 2009 Jan 10;27(2):186-92 - PubMed
  77. Cancer. 1996 Apr 15;77(8 Suppl):1729-35 - PubMed
  78. Br J Surg. 1999 Mar;86(3):332-7 - PubMed
  79. PLoS One. 2013 Jun 03;8(6):e65117 - PubMed
  80. Cancer Immunol Immunother. 2007 Nov;56(11):1701-10 - PubMed
  81. Ann Surg Oncol. 2016 Apr;23 (4):1352-60 - PubMed
  82. Cancer. 1996 Apr 1;77(7):1254-62 - PubMed
  83. Ann Surg. 1984 Mar;199(3):306-16 - PubMed
  84. Ann Surg Oncol. 2008 Mar;15(3):677-9 - PubMed
  85. J Pathol. 1997 Jul;182(3):318-24 - PubMed
  86. Chir Ital. 2005 Sep-Oct;57(5):555-70 - PubMed
  87. J Immunol. 1999 Aug 15;163(4):2314-21 - PubMed
  88. Surg Oncol Clin N Am. 2003 Jan;12 (1):91-103 - PubMed
  89. Ann Surg. 2018 Mar;267(3):514-520 - PubMed
  90. Ann Surg. 1989 Apr;209(4):428-34 - PubMed
  91. Clin Epidemiol. 2012;4:283-301 - PubMed
  92. Annu Rev Immunol. 2004;22:329-60 - PubMed
  93. Hepatology. 2006 Feb;43(2 Suppl 1):S54-62 - PubMed
  94. Ann Surg. 2000 Apr;231(4):487-99 - PubMed
  95. J Immunol. 2015 Mar 15;194(6):2467-71 - PubMed
  96. Gastroenterology. 2010 Apr;138(4):1429-40 - PubMed
  97. Nature. 2001 Apr 26;410(6832):1107-11 - PubMed
  98. Am J Surg. 2001 Jul;182(1):81-8 - PubMed
  99. Surg Today. 1992;22(3):260-4 - PubMed
  100. Am J Physiol Lung Cell Mol Physiol. 2015 Jun 1;308(11):L1178-88 - PubMed
  101. Ann Surg. 1999 Sep;230(3):309-18; discussion 318-21 - PubMed
  102. Ann Surg Oncol. 2009 Aug;16(8):2138-46 - PubMed
  103. Br J Surg. 1991 Jul;78(7):797-801 - PubMed
  104. Ann Oncol. 2014 May;25(5):1018-25 - PubMed

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