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Marcioli MAR, Silva JLDC, Ribeiro LFC, et al. Neurotrophin expression and histomorphometric evaluation in Wistar rats subjected to neural mobilization after compression of the median nerve. Rev Bras Ortop. 2018;53(3):276-280doi: 10.1016/j.rboe.2018.03.006.
Marcioli, M. A. R., Silva, J. L. D. C., Ribeiro, L. F. C., Brancalhão, R. M. C., & Bertolini, G. R. F. (2018). Neurotrophin expression and histomorphometric evaluation in Wistar rats subjected to neural mobilization after compression of the median nerve. Revista brasileira de ortopedia, 53(3), 276-280. https://doi.org/10.1016/j.rboe.2018.03.006
Marcioli, Marieli Araujo Rossoni, et al. "Neurotrophin expression and histomorphometric evaluation in Wistar rats subjected to neural mobilization after compression of the median nerve." Revista brasileira de ortopedia vol. 53,3 (2018): 276-280. doi: https://doi.org/10.1016/j.rboe.2018.03.006
Marcioli MAR, Silva JLDC, Ribeiro LFC, Brancalhão RMC, Bertolini GRF. Neurotrophin expression and histomorphometric evaluation in Wistar rats subjected to neural mobilization after compression of the median nerve. Rev Bras Ortop. 2018 Apr 04;53(3):276-280. doi: 10.1016/j.rboe.2018.03.006. eCollection 2018. PMID: 29892576; PMCID: PMC5993878.
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Rev Bras Ortop. 2018 Apr 04;53(3):276-280. doi: 10.1016/j.rboe.2018.03.006. eCollection 2018.

Neurotrophin expression and histomorphometric evaluation in Wistar rats subjected to neural mobilization after compression of the median nerve.

Revista brasileira de ortopedia

Marieli Araujo Rossoni Marcioli, José Luis da Conceição Silva, Lucinéia de Fátima Chasko Ribeiro, Rose Meire Costa Brancalhão, Gladson Ricardo Flor Bertolini

Affiliations

  1. Universidade Estadual do Oeste do Paraná (Unioeste), Cascavel, PR, Brazil.
  2. Programa de Ciências Farmacêuticas, Universidade Estadual do Oeste do Paraná (Unioeste), Cascavel, PR, Brazil.
  3. Programa de Biociências e Saúde, Universidade Estadual do Oeste do Paraná (Unioeste), Cascavel, PR, Brazil.

PMID: 29892576 PMCID: PMC5993878 DOI: 10.1016/j.rboe.2018.03.006

Abstract

OBJECTIVE: To evaluate the neurotrophin mRNA expression and axon count in the median nerve of Wistar rats submitted to neural mobilization (NM) after nerve compression.

METHODS: Eighteen animals were randomly divided into G1 (nerve compression only), G2 (NM for 1 min), and G3 (NM for 3 min). For NM, the animals were anesthetized and the right scapula received the mobilization, adapted as indicated for humans, on alternate days, from the third to the 13th postoperative (PO) day, totaling six days of therapy. On the 14th PO day, animals were anesthetized and euthanized. Fragments of the median nerve, distal to the compression procedure, were removed for histomorphometric analysis and expression of neurotrophins, nerve growth factor (NGF), and brain-derived neurotrophic factor (BDNF) by RT-PCR.

RESULTS: Histomorphometric analysis revealed differences in the number of axons in the injured side, which was significantly lower in the injured limb nerve compared to the control limb, whereas the RT-PCR analysis showed no significant differences in the expression of NGF or BDNF.

CONCLUSION: NM treatment did not affect median nerve regeneration, which maintained normal recovery rates.

Keywords: Exercise; Histology; Intercellular signaling peptides and proteins; Median nerve; Nerve regeneration

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