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Hart RJ, Frederiksen H, Doherty DA, et al. The Possible Impact of Antenatal Exposure to Ubiquitous Phthalates Upon Male Reproductive Function at 20 Years of Age. Front Endocrinol (Lausanne). 2018;9:288doi: 10.3389/fendo.2018.00288.
Hart, R. J., Frederiksen, H., Doherty, D. A., Keelan, J. A., Skakkebaek, N. E., Minaee, N. S., McLachlan, R., Newnham, J. P., Dickinson, J. E., Pennell, C. E., Norman, R. J., & Main, K. M. (2018). The Possible Impact of Antenatal Exposure to Ubiquitous Phthalates Upon Male Reproductive Function at 20 Years of Age. Frontiers in endocrinology, 9288. https://doi.org/10.3389/fendo.2018.00288
Hart, Roger J, et al. "The Possible Impact of Antenatal Exposure to Ubiquitous Phthalates Upon Male Reproductive Function at 20 Years of Age." Frontiers in endocrinology vol. 9 (2018): 288. doi: https://doi.org/10.3389/fendo.2018.00288
Hart RJ, Frederiksen H, Doherty DA, Keelan JA, Skakkebaek NE, Minaee NS, McLachlan R, Newnham JP, Dickinson JE, Pennell CE, Norman RJ, Main KM. The Possible Impact of Antenatal Exposure to Ubiquitous Phthalates Upon Male Reproductive Function at 20 Years of Age. Front Endocrinol (Lausanne). 2018 Jun 04;9:288. doi: 10.3389/fendo.2018.00288. eCollection 2018. PMID: 29922230; PMCID: PMC5996240.
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Front Endocrinol (Lausanne). 2018 Jun 04;9:288. doi: 10.3389/fendo.2018.00288. eCollection 2018.

The Possible Impact of Antenatal Exposure to Ubiquitous Phthalates Upon Male Reproductive Function at 20 Years of Age.

Frontiers in endocrinology

Roger J Hart, Hanne Frederiksen, Dorota A Doherty, Jeffrey A Keelan, Niels E Skakkebaek, Noviani S Minaee, Robert McLachlan, John P Newnham, Jan E Dickinson, Craig E Pennell, Robert J Norman, Katharina M Main

Affiliations

  1. Division of Obstetrics & Gynaecology, University of Western Australia, Perth, WA, Australia.
  2. Fertility Specialists of Western Australia, Bethesda Hospital, Claremont, WA, Australia.
  3. Department of Growth and Reproduction and EDMaRC, Rigshospitalet, University of Copenhagen, Copenhagen, Denmark.
  4. Women and Infants Research Foundation, King Edward Memorial Hospital, Perth, WA, Australia.
  5. Hudson Institute of Medical Research, Monash Medical Centre, Melbourne, VIC, Australia.
  6. Robinson Research Institute, University of Adelaide, Adelaide, SA, Australia.

PMID: 29922230 PMCID: PMC5996240 DOI: 10.3389/fendo.2018.00288

Abstract

Phthalates are ubiquitous environmental endocrine-disrupting chemicals suspected to interfere with developmental androgen action leading to adverse effects on male reproductive function. Prenatal exposure studies in rodents show cryptorchidism, hypospadias and reduced testicular volume (TV), testosterone and anogenital distance in males. It is postulated that there is a developmental window

Keywords: Raine; endocrine disrupter; sperm count; testicular volume; testosterone

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