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Chiaradonna F, Ricciardiello F, Palorini R. The Nutrient-Sensing Hexosamine Biosynthetic Pathway as the Hub of Cancer Metabolic Rewiring. Cells. 2018;7(6)doi: 10.3390/cells7060053.
Chiaradonna, F., Ricciardiello, F., & Palorini, R. (2018). The Nutrient-Sensing Hexosamine Biosynthetic Pathway as the Hub of Cancer Metabolic Rewiring. Cells, 7(6), . https://doi.org/10.3390/cells7060053
Chiaradonna, Ferdinando, et al. "The Nutrient-Sensing Hexosamine Biosynthetic Pathway as the Hub of Cancer Metabolic Rewiring." Cells vol. 7,6 (2018). doi: https://doi.org/10.3390/cells7060053
Chiaradonna F, Ricciardiello F, Palorini R. The Nutrient-Sensing Hexosamine Biosynthetic Pathway as the Hub of Cancer Metabolic Rewiring. Cells. 2018 Jun 02;7(6). doi: 10.3390/cells7060053. PMID: 29865240; PMCID: PMC6025041.
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Cells. 2018 Jun 02;7(6). doi: 10.3390/cells7060053.

The Nutrient-Sensing Hexosamine Biosynthetic Pathway as the Hub of Cancer Metabolic Rewiring.

Cells

Ferdinando Chiaradonna, Francesca Ricciardiello, Roberta Palorini

Affiliations

  1. Department of Biotechnology and Biosciences, University of Milano-Bicocca, Milan 20126, Italy. [email protected].
  2. Department of Biotechnology and Biosciences, University of Milano-Bicocca, Milan 20126, Italy. [email protected].
  3. Department of Biotechnology and Biosciences, University of Milano-Bicocca, Milan 20126, Italy. [email protected].

PMID: 29865240 PMCID: PMC6025041 DOI: 10.3390/cells7060053

Abstract

Alterations in glucose and glutamine utilizing pathways and in fatty acid metabolism are currently considered the most significant and prevalent metabolic changes observed in almost all types of tumors. Glucose, glutamine and fatty acids are the substrates for the hexosamine biosynthetic pathway (HBP). This metabolic pathway generates the "sensing molecule" UDP-

Keywords: UDP-GlcNAc; bioenergetics; cancer; hexosamine biosynthesis pathway; metabolism; protein glycosylation

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