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Samarah F, Srour MA, Yaseen D, et al. Frequency of Red Blood Cell Alloimmunization in Patients with Sickle Cell Disease in Palestine. Adv Hematol. 2018;2018:5356245doi: 10.1155/2018/5356245.
Samarah, F., Srour, M. A., Yaseen, D., & Dumaidi, K. (2018). Frequency of Red Blood Cell Alloimmunization in Patients with Sickle Cell Disease in Palestine. Advances in hematology, 20185356245. https://doi.org/10.1155/2018/5356245
Samarah, Fekri, et al. "Frequency of Red Blood Cell Alloimmunization in Patients with Sickle Cell Disease in Palestine." Advances in hematology vol. 2018 (2018): 5356245. doi: https://doi.org/10.1155/2018/5356245
Samarah F, Srour MA, Yaseen D, Dumaidi K. Frequency of Red Blood Cell Alloimmunization in Patients with Sickle Cell Disease in Palestine. Adv Hematol. 2018 Jun 06;2018:5356245. doi: 10.1155/2018/5356245. eCollection 2018. PMID: 29977298; PMCID: PMC6011130.
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Adv Hematol. 2018 Jun 06;2018:5356245. doi: 10.1155/2018/5356245. eCollection 2018.

Frequency of Red Blood Cell Alloimmunization in Patients with Sickle Cell Disease in Palestine.

Advances in hematology

Fekri Samarah, Mahmoud A Srour, Dirgham Yaseen, Kamal Dumaidi

Affiliations

  1. Department of Medical Technology, Faculty of Allied Health Sciences, Arab American University in Jenin, State of Palestine.
  2. Department of Biology and Biochemistry, Faculty of Science, Birzeit University, Birzeit, State of Palestine.
  3. Rafidia Governmental Hospital, Ministry of Health, Nablus, State of Palestine.

PMID: 29977298 PMCID: PMC6011130 DOI: 10.1155/2018/5356245

Abstract

BACKGROUND: Transfusion of red blood cells (RBC) is an essential therapeutic tool in sickle cell disease (SCD). Repeated RBC transfusions can cause alloimmunization which causes difficulty in cross-matching and finding compatible blood for transfusions. This study aimed to investigate the frequency of RBC alloimmunization and related risk factors among Palestinian SCD patients.

MATERIALS AND METHODS: A multicenter cross-sectional study on 116 previously transfused SCD patients from three centers in West Bank, Palestine. Demographic, medical data and history of transfusion were recorded. Blood samples were collected from transfused consenting SCD patients. Gel card method was used for antibody screening and identification. In all patients, autocontrol and direct antiglobulin (DAT) test were performed using polyspecific (anti-IgG + C3d) anti-human globulin (AHG) gel cards for the detection of autoantibodies.

RESULTS: Of the SCD patients, 62 (53.4%) patients were HbSS and 54 (46.6%) patients were sickle

CONCLUSIONS: RBC alloimmunization rate among Palestinian SCD patients is low compared to neighboring countries and countries all over the world but still warrants more attention. Phenotyping of donors/recipients' RBC for Rh antigens and K

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