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Takamatsu S, Murakami K, Takaya H, et al. Malignant psoas syndrome associated with gynecological malignancy: Three case reports and a review of the literature. Mol Clin Oncol. 2018;9(1):82-86doi: 10.3892/mco.2018.1635.
Takamatsu, S., Murakami, K., Takaya, H., Tobiume, T., Nakai, H., Suzuki, A., Mandai, M., & Matsumura, N. (2018). Malignant psoas syndrome associated with gynecological malignancy: Three case reports and a review of the literature. Molecular and clinical oncology, 9(1), 82-86. https://doi.org/10.3892/mco.2018.1635
Takamatsu, Shiro, et al. "Malignant psoas syndrome associated with gynecological malignancy: Three case reports and a review of the literature." Molecular and clinical oncology vol. 9,1 (2018): 82-86. doi: https://doi.org/10.3892/mco.2018.1635
Takamatsu S, Murakami K, Takaya H, Tobiume T, Nakai H, Suzuki A, Mandai M, Matsumura N. Malignant psoas syndrome associated with gynecological malignancy: Three case reports and a review of the literature. Mol Clin Oncol. 2018 Jul;9(1):82-86. doi: 10.3892/mco.2018.1635. Epub 2018 May 21. PMID: 29977543; PMCID: PMC6031012.
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Mol Clin Oncol. 2018 Jul;9(1):82-86. doi: 10.3892/mco.2018.1635. Epub 2018 May 21.

Malignant psoas syndrome associated with gynecological malignancy: Three case reports and a review of the literature.

Molecular and clinical oncology

Shiro Takamatsu, Kosuke Murakami, Hisamitsu Takaya, Takako Tobiume, Hidekatsu Nakai, Ayako Suzuki, Masaki Mandai, Noriomi Matsumura

Affiliations

  1. Department of Obstetrics and Gynecology, Kindai University Faculty of Medicine, Osakasayama, Osaka 589-8511, Japan.
  2. Department of Gynecology and Obstetrics, Kyoto University Graduate School of Medicine, Kyoto, Osaka 606-8507, Japan.

PMID: 29977543 PMCID: PMC6031012 DOI: 10.3892/mco.2018.1635

Abstract

Malignant psoas syndrome (MPS) is a rare and unique cancer-associated syndrome caused by the malignant involvement of the psoas major muscle, and is characterized by ipsilateral lumbosacral plexopathy and painful hip flexion. The pain in MPS is often distressing and intractable, and there is no established effective treatment approach. Herein, the present study reports on three cases of MPS associated with gynecological malignancies, wherein symptom improvement was observed following chemotherapy or radiotherapy. Among 39 cases documented in the literature, female genital tract malignancies were the most frequent causes of MPS; however, the condition may be under-diagnosed, owing to the lack of general recognition. Considering the development of recent high-precision radiation therapy, palliative radiotherapy may serve an important role in the management of MPS. For physicians treating gynecological cancers, early detection of MPS is clinically important as this may allow patients to receive possible therapies and improve their quality of life in end-stage cancer. Further prospective studies should be performed to evaluate effective therapeutic approaches for MPS.

Keywords: gynecological cancer; lumbosacral plexopathy; malignant psoas syndrome; palliative radiotherapy; radiotherapy

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