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da Silva FBR, Cunha PA, Ribera PC, et al. Heavy Chronic Ethanol Exposure From Adolescence to Adulthood Induces Cerebellar Neuronal Loss and Motor Function Damage in Female Rats. Front Behav Neurosci. 2018;12:88doi: 10.3389/fnbeh.2018.00088.
da Silva, F. B. R., Cunha, P. A., Ribera, P. C., Barros, M. A., Cartágenes, S. C., Fernandes, L. M. P., Teixeira, F. B., Fontes-Júnior, E. A., Prediger, R. D., Lima, R. R., & Maia, C. S. F. (2018). Heavy Chronic Ethanol Exposure From Adolescence to Adulthood Induces Cerebellar Neuronal Loss and Motor Function Damage in Female Rats. Frontiers in behavioral neuroscience, 1288. https://doi.org/10.3389/fnbeh.2018.00088
da Silva, Fernando B R, et al. "Heavy Chronic Ethanol Exposure From Adolescence to Adulthood Induces Cerebellar Neuronal Loss and Motor Function Damage in Female Rats." Frontiers in behavioral neuroscience vol. 12 (2018): 88. doi: https://doi.org/10.3389/fnbeh.2018.00088
da Silva FBR, Cunha PA, Ribera PC, Barros MA, Cartágenes SC, Fernandes LMP, Teixeira FB, Fontes-Júnior EA, Prediger RD, Lima RR, Maia CSF. Heavy Chronic Ethanol Exposure From Adolescence to Adulthood Induces Cerebellar Neuronal Loss and Motor Function Damage in Female Rats. Front Behav Neurosci. 2018 May 15;12:88. doi: 10.3389/fnbeh.2018.00088. eCollection 2018. PMID: 29867389; PMCID: PMC5968384.
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Front Behav Neurosci. 2018 May 15;12:88. doi: 10.3389/fnbeh.2018.00088. eCollection 2018.

Heavy Chronic Ethanol Exposure From Adolescence to Adulthood Induces Cerebellar Neuronal Loss and Motor Function Damage in Female Rats.

Frontiers in behavioral neuroscience

Fernando B R da Silva, Polyane A Cunha, Paula C Ribera, Mayara A Barros, Sabrina C Cartágenes, Luanna M P Fernandes, Francisco B Teixeira, Enéas A Fontes-Júnior, Rui D Prediger, Rafael R Lima, Cristiane S F Maia

Affiliations

  1. Laboratory of Pharmacology of Inflammation and Behavior (LAFICO), Institute of Health Sciences, Universidade Federal do Pará, Belém, Brazil.
  2. Laboratory of Functional and Structural Biology, Institute of Biological Sciences, Universidade Federal do Pará, Belém, Brazil.
  3. Laboratório Experimental de Doenças Neurodegenerativas (LEXDON), Department of Pharmacology, Center of Biological Sciences, Universidade Federal de Santa Catarina, Florianópolis, Brazil.

PMID: 29867389 PMCID: PMC5968384 DOI: 10.3389/fnbeh.2018.00088

Abstract

Over the last years, heavy ethanol consumption by teenagers/younger adults has increased considerably among females. However, few studies have addressed the long-term impact on brain structures' morphology and function of chronic exposure to high ethanol doses from adolescence to adulthood in females. In line with this idea, in the current study we investigated whether heavy chronic ethanol exposure during adolescence to adulthood may induce motor impairments and morphological and cellular alterations in the cerebellum of female rats. Adolescent female Wistar rats (35 days old) were treated with distilled water or ethanol (6.5 g/kg/day, 22.5% w/v) during 55 days by gavage. At 90 days of age, motor function of animals was assessed using open field (OF), pole, beam walking and rotarod tests. Following completion of behavioral tests, morphological and immunohistochemical analyses of the cerebellum were performed. Chronic ethanol exposure impaired significantly motor performance of female rats, inducing spontaneous locomotor activity deficits, bradykinesia, incoordination and motor learning disruption. Moreover, histological analysis revealed that ethanol exposure induced atrophy and neuronal loss in the cerebellum. These findings indicate that heavy ethanol exposure during adolescence is associated with long-lasting cerebellar degeneration and motor impairments in female rats.

Keywords: adolescence; cerebellar atrophy; cerebellum; ethanol; motor deficits

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