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van der Kraan PM. Differential Role of Transforming Growth Factor-beta in an Osteoarthritic or a Healthy Joint. J Bone Metab. 2018;25(2):65-72doi: 10.11005/jbm.2018.25.2.65.
van der Kraan, P. M. (2018). Differential Role of Transforming Growth Factor-beta in an Osteoarthritic or a Healthy Joint. Journal of bone metabolism, 25(2), 65-72. https://doi.org/10.11005/jbm.2018.25.2.65
van der Kraan, Peter M. "Differential Role of Transforming Growth Factor-beta in an Osteoarthritic or a Healthy Joint." Journal of bone metabolism vol. 25,2 (2018): 65-72. doi: https://doi.org/10.11005/jbm.2018.25.2.65
van der Kraan PM. Differential Role of Transforming Growth Factor-beta in an Osteoarthritic or a Healthy Joint. J Bone Metab. 2018 May;25(2):65-72. doi: 10.11005/jbm.2018.25.2.65. Epub 2018 May 31. PMID: 29900155; PMCID: PMC5995759.
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J Bone Metab. 2018 May;25(2):65-72. doi: 10.11005/jbm.2018.25.2.65. Epub 2018 May 31.

Differential Role of Transforming Growth Factor-beta in an Osteoarthritic or a Healthy Joint.

Journal of bone metabolism

Peter M van der Kraan

Affiliations

  1. Department of Rheumatology, Experimental Rheumatology, Radboud University Medical Center, Nijmegen, Netherlands.

PMID: 29900155 PMCID: PMC5995759 DOI: 10.11005/jbm.2018.25.2.65

Abstract

Transforming growth factor-β (TGF-β) is a cytokine that plays an important role in both normal joints and joints affected by osteoarthritis (OA), the most common joint disease. However, the role of this pleiotropic cytokine in a normal healthy joint is very different from its role in an OA joint. In a normal synovial joint, active TGF-β is only present after joint loading and only for a short period. In contrast, permanent and high levels of active TGF-β are detected in OA joints. Due to this difference in levels and exposure period of joint cells to active TGF-β, the function of TGF-β is strikingly different in normal and OA joints. The consequences of this difference in TGF-β levels on joint homeostasis and pathological changes in OA joints are discussed in this review.

Keywords: Cytokines; Osteoarthritis; Transforming growth factor beta

Conflict of interest statement

No potential conflict of interest relevant to this article was reported.

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