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Akouchekian S, Omranifard V, Moshfegh P, et al. The Effect of Atorvastatin on Obsessive-compulsive Symptoms of Refractory Obsessive-compulsive Disorder (Add-on Therapy). Adv Biomed Res. 2018;7:90doi: 10.4103/abr.abr_114_16.
Akouchekian, S., Omranifard, V., Moshfegh, P., Maracy, M. R., & Almasi, A. (2018). The Effect of Atorvastatin on Obsessive-compulsive Symptoms of Refractory Obsessive-compulsive Disorder (Add-on Therapy). Advanced biomedical research, 790. https://doi.org/10.4103/abr.abr_114_16
Akouchekian, Shahla, et al. "The Effect of Atorvastatin on Obsessive-compulsive Symptoms of Refractory Obsessive-compulsive Disorder (Add-on Therapy)." Advanced biomedical research vol. 7 (2018): 90. doi: https://doi.org/10.4103/abr.abr_114_16
Akouchekian S, Omranifard V, Moshfegh P, Maracy MR, Almasi A. The Effect of Atorvastatin on Obsessive-compulsive Symptoms of Refractory Obsessive-compulsive Disorder (Add-on Therapy). Adv Biomed Res. 2018 May 29;7:90. doi: 10.4103/abr.abr_114_16. eCollection 2018. PMID: 29930930; PMCID: PMC5991271.
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Adv Biomed Res. 2018 May 29;7:90. doi: 10.4103/abr.abr_114_16. eCollection 2018.

The Effect of Atorvastatin on Obsessive-compulsive Symptoms of Refractory Obsessive-compulsive Disorder (Add-on Therapy).

Advanced biomedical research

Shahla Akouchekian, Victoria Omranifard, Parivash Moshfegh, Mohammad Reza Maracy, Asiyeh Almasi

Affiliations

  1. Behavioral Sciences Research Center, Isfahan University of Medical Sciences, Isfahan, Iran.
  2. Psychosomatic Research Center, Isfahan University of Medical Sciences, Isfahan, Iran.
  3. Department of Psychiatry, Medical School, University of Medical Sciences, Isfahan, Iran.
  4. Department of Epidemiology and Biostatistics, School of Public Health, Isfahan University of Medical Sciences, Isfahan, Iran.

PMID: 29930930 PMCID: PMC5991271 DOI: 10.4103/abr.abr_114_16

Abstract

BACKGROUND: Considering the effect of statins on the regulation of dopamine neurotransmitters and glutamates and importance of the treatment of obsessive-compulsive disorder (OCD) due to its relatively high prevalence and disability of available drugs in treatment of many patients, we came to the point to examine effectiveness of statins in patients with OCD.

MATERIALS AND METHODS: This study is a double-blind randomized clinical trial, which is done in OCD clinic of Isfahan Shariati in 2014 for 1 year. The target population consists of 64 patients with OCD; one group is given a daily 40 mg atorvastatin tablets and the other group receives placebo. At baseline, 4- and 8-week severities of obsessive-compulsive symptoms are measured using Yale-Brown scale and compared in the two groups.

RESULTS: The study results show a statistically significant difference between the two groups of intervention and control (

CONCLUSION: Overall, the evidences obtained from the study declare the effects of adding statins to treat obsessive-compulsive symptoms.

Keywords: Add-on therapy; atorvastatin; obsessive-compulsive disorder; refractory obsessive-compulsive disorder

Conflict of interest statement

There are no conflicts of interest.

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