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Ulusoy H, Akgol G, Gulkesen A, et al. Serum heat-shock protein-65 antibody levels are elevated but not associated with disease activity in patients with rheumatoid arthritis and ankylosing spondylitis. Open Access Rheumatol. 2018;10:55-60doi: 10.2147/OARRR.S162512.
Ulusoy, H., Akgol, G., Gulkesen, A., Kaya, A., Ayden Kal, G., Kaman, D., & Tuncer, T. (2018). Serum heat-shock protein-65 antibody levels are elevated but not associated with disease activity in patients with rheumatoid arthritis and ankylosing spondylitis. Open access rheumatology : research and reviews, 1055-60. https://doi.org/10.2147/OARRR.S162512
Ulusoy, Hasan, et al. "Serum heat-shock protein-65 antibody levels are elevated but not associated with disease activity in patients with rheumatoid arthritis and ankylosing spondylitis." Open access rheumatology : research and reviews vol. 10 (2018): 55-60. doi: https://doi.org/10.2147/OARRR.S162512
Ulusoy H, Akgol G, Gulkesen A, Kaya A, Ayden Kal G, Kaman D, Tuncer T. Serum heat-shock protein-65 antibody levels are elevated but not associated with disease activity in patients with rheumatoid arthritis and ankylosing spondylitis. Open Access Rheumatol. 2018 May 25;10:55-60. doi: 10.2147/OARRR.S162512. eCollection 2018. PMID: 29872356; PMCID: PMC5973434.
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Open Access Rheumatol. 2018 May 25;10:55-60. doi: 10.2147/OARRR.S162512. eCollection 2018.

Serum heat-shock protein-65 antibody levels are elevated but not associated with disease activity in patients with rheumatoid arthritis and ankylosing spondylitis.

Open access rheumatology : research and reviews

Hasan Ulusoy, Gurkan Akgol, Arif Gulkesen, Arzu Kaya, Gul Ayden Kal, Dilara Kaman, Turkan Tuncer

Affiliations

  1. Department of Rheumatology, Medicana International Samsun Hospital, Samsun, Turkey.
  2. Division of Rheumatology, Department of Physical Medicine and Rehabilitation, Firat University, Faculty of Medicine, Elazig, Turkey.
  3. Department of Biochemistry, Firat University, Faculty of Medicine, Elazig, Turkey.

PMID: 29872356 PMCID: PMC5973434 DOI: 10.2147/OARRR.S162512

Abstract

OBJECTIVES: Heat-shock proteins (HSPs) have gained increased interest for their role in autoimmune disorders. These proteins are targeted by the immune system in various autoimmune diseases. The aim of this study was to assess the serum heat-shock protein-65 antibody (anti-HSP65) levels and their clinical significance in patients with rheumatoid arthritis (RA) and ankylosing spondylitis (AS).

PATIENTS AND METHODS: A total of 30 patients with RA, 30 patients with AS, and 30 healthy controls were enrolled in this study. All patients were assessed using routine clinical and laboratory evaluations. Serum anti-HSP65 levels were determined by ELISA.

RESULTS: Serum anti-HSP65 levels of both RA and AS patients were significantly higher than those of controls (

CONCLUSION: In this study, serum anti-HSP65 levels were increased, but not associated with disease activity in both RA and AS patients. These results suggest that HSP antigens may play a role in the pathogenesis. However, further follow-up studies are needed. Identification of target antigens such as HSP65 is vital to developing new immunotherapeutic agents.

Keywords: HSP; ankylosing spondylitis; heat-shock protein; rheumatoid arthritis

Conflict of interest statement

Disclosure The authors report no conflicts of interest in this work.

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