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Gugala N, Lemire J, Chatfield-Reed K, et al. Using a Chemical Genetic Screen to Enhance Our Understanding of the Antibacterial Properties of Silver. Genes (Basel). 2018;9(7)doi: 10.3390/genes9070344.
Gugala, N., Lemire, J., Chatfield-Reed, K., Yan, Y., Chua, G., & Turner, R. J. (2018). Using a Chemical Genetic Screen to Enhance Our Understanding of the Antibacterial Properties of Silver. Genes, 9(7), . https://doi.org/10.3390/genes9070344
Gugala, Natalie, et al. "Using a Chemical Genetic Screen to Enhance Our Understanding of the Antibacterial Properties of Silver." Genes vol. 9,7 (2018). doi: https://doi.org/10.3390/genes9070344
Gugala N, Lemire J, Chatfield-Reed K, Yan Y, Chua G, Turner RJ. Using a Chemical Genetic Screen to Enhance Our Understanding of the Antibacterial Properties of Silver. Genes (Basel). 2018 Jul 06;9(7). doi: 10.3390/genes9070344. PMID: 29986482; PMCID: PMC6071238.
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Genes (Basel). 2018 Jul 06;9(7). doi: 10.3390/genes9070344.

Using a Chemical Genetic Screen to Enhance Our Understanding of the Antibacterial Properties of Silver.

Genes

Natalie Gugala, Joe Lemire, Kate Chatfield-Reed, Ying Yan, Gordon Chua, Raymond J Turner

Affiliations

  1. Department of Biological Sciences, University of Calgary, 2500 University Dr. NW, Calgary, AB T2N 1N4, Canada. [email protected].
  2. Department of Biological Sciences, University of Calgary, 2500 University Dr. NW, Calgary, AB T2N 1N4, Canada. [email protected].
  3. Department of Biological Sciences, University of Calgary, 2500 University Dr. NW, Calgary, AB T2N 1N4, Canada. [email protected].
  4. Department of Mathematics and Statistics, University of Calgary, 2500 University Dr. NW, Calgary, AB T2N 1N4, Canada. [email protected].
  5. Department of Biological Sciences, University of Calgary, 2500 University Dr. NW, Calgary, AB T2N 1N4, Canada. [email protected].
  6. Department of Biological Sciences, University of Calgary, 2500 University Dr. NW, Calgary, AB T2N 1N4, Canada. [email protected].

PMID: 29986482 PMCID: PMC6071238 DOI: 10.3390/genes9070344

Abstract

It is essential to understand the mechanisms by which a toxicant is capable of poisoning the bacterial cell. The mechanism of action of many biocides and toxins, including numerous ubiquitous compounds, is not fully understood. For example, despite the widespread clinical and commercial use of silver (Ag), the mechanisms describing how this metal poisons bacterial cells remains incomplete. To advance our understanding surrounding the antimicrobial action of Ag, we performed a chemical genetic screen of a mutant library of

Keywords: Escherichia coli; Keio collection; antimicrobials; silver; silver resistance; silver toxicity

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