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Biu E, Beraj S, Vyshka G, et al. Transfusion of Fresh Frozen Plasma in Critically Ill Patients: Effective or Useless?. Open Access Maced J Med Sci. 2018;6(5):820-823doi: 10.3889/oamjms.2018.212.
Biu, E., Beraj, S., Vyshka, G., Nunci, L., & Çina, T. (2018). Transfusion of Fresh Frozen Plasma in Critically Ill Patients: Effective or Useless?. Open access Macedonian journal of medical sciences, 6(5), 820-823. https://doi.org/10.3889/oamjms.2018.212
Biu, Ermira, et al. "Transfusion of Fresh Frozen Plasma in Critically Ill Patients: Effective or Useless?." Open access Macedonian journal of medical sciences vol. 6,5 (2018): 820-823. doi: https://doi.org/10.3889/oamjms.2018.212
Biu E, Beraj S, Vyshka G, Nunci L, Çina T. Transfusion of Fresh Frozen Plasma in Critically Ill Patients: Effective or Useless?. Open Access Maced J Med Sci. 2018 May 17;6(5):820-823. doi: 10.3889/oamjms.2018.212. eCollection 2018 May 20. PMID: 29875852; PMCID: PMC5985894.
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Open Access Maced J Med Sci. 2018 May 17;6(5):820-823. doi: 10.3889/oamjms.2018.212. eCollection 2018 May 20.

Transfusion of Fresh Frozen Plasma in Critically Ill Patients: Effective or Useless?.

Open access Macedonian journal of medical sciences

Ermira Biu, Silvana Beraj, Gentian Vyshka, Lordian Nunci, Tatjana Çina

Affiliations

  1. Department of Para-clinical Sciences, Faculty of Technical Medical Sciences, University of Medicine in Tirana, Tirana, Albania.
  2. Biomedical and Experimental Department, Faculty of Medicine, University of Medicine in Tirana, Tirana, Albania.
  3. Central Anaesthesiology and Intensive Care Service, University Hospital Center "Mother Theresa", Tirana, Albania.

PMID: 29875852 PMCID: PMC5985894 DOI: 10.3889/oamjms.2018.212

Abstract

BACKGROUND: Fresh frozen plasma (FFP) is widely used in critically ill patients to correct the deficiency of coagulation factors or increased INR.

AIM: In the present study we aimed to evaluate the outcome of the freshly frozen plasma use as prophylaxis in ICU patients before an invasive procedure.

METHODS: The study was conducted at Central Anaesthesiology and Intensive Care Service UHCT "Mother Theresa", Tirana. 136 patients were enrolled with coagulopathy with no bleeding before the invasive procedure, from June 2016 to December 2016. A group of 75 patients underwent a median volume of 12.5 ml/kg FFP given, and 61 had no transfusion. Data were collected on demographics, the severity of illness measured by APACHE III scores, INR, medication use, hemodynamic data.

RESULTS: From 136 patients with coagulopathy with no bleeding who underwent planned invasive interventions, 75 [55%] received FFP, vs 61 [45%] p = 0.04 who did not receive. Overall, the median FFP dose was 12.5 ml kg-1. Median INR level in FFP and non-FFP groups was respectively 3.1 (1.9-4.8) and 3.5 (1.8-5.2). INR was corrected in 24 of 75 (32%) of those who received a transfusion. The frequency of minor bleeding episodes was 9.3% in transfused patients vs 4.9% in the non-transfused group. Patients who developed an onset of acute lung injury were more frequent in the FFP group. No allergic transfusion complications were observed. Also, the median length of hospital stay [LOS] was 3.05 days vs 2.91 days and mortality rate 8.2% vs 6.5% with no significant difference between two groups.

CONCLUSIONS: Freshly frozen plasma transfusions are often unnecessarily administered during an inadequate correction of the deficiencies of coagulation factors. When comparing a liberal FFP transfusion strategy vs restrictive other clinical trials are required to asses which one is the best to adopt in intensive care settings.

Keywords: Fresh frozen plasma; Increased INR; Invasive procedure; Transfusion

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