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Org Biomol Chem. 2018 Jul 25;16(29):5232-5235. doi: 10.1039/c8ob01184b.

Fe-Catalyzed tandem cyclization for the synthesis of 3-nitrofurans from homopropargylic alcohols and Al(NO.

Organic & biomolecular chemistry

Ting Wang, Yong Jiang, Yanyan Wang, Rulong Yan

Affiliations

  1. State Key Laboratory of Applied Organic Chemistry, Key Laboratory of Nonferrous Metal Chemistry and Resources Utilization of Gansu Province, Department of Chemistry, Lanzhou University, Lanzhou, Gansu, China. [email protected].

PMID: 29989633 DOI: 10.1039/c8ob01184b

Abstract

Al(NO3)3·9H2O as a nitro source for the synthesis of 3-nitrofurans from homopropargylic alcohols through Fe-catalyzed tandem cyclization is described. In this transformation, the substituted nitrofurans are obtained through nitration and cyclization. The substrate homopropargylic alcohols with different groups participate smoothly in this process and the desired substituted nitrofurans were obtained in moderate yields.

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