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Jung RG, Motazedian P, Ramirez FD, et al. Association between plasminogen activator inhibitor-1 and cardiovascular events: a systematic review and meta-analysis. Thromb J. 2018;16:12doi: 10.1186/s12959-018-0166-4.
Jung, R. G., Motazedian, P., Ramirez, F. D., Simard, T., Di Santo, P., Visintini, S., Faraz, M. A., Labinaz, A., Jung, Y., & Hibbert, B. (2018). Association between plasminogen activator inhibitor-1 and cardiovascular events: a systematic review and meta-analysis. Thrombosis journal, 1612. https://doi.org/10.1186/s12959-018-0166-4
Jung, Richard G, et al. "Association between plasminogen activator inhibitor-1 and cardiovascular events: a systematic review and meta-analysis." Thrombosis journal vol. 16 (2018): 12. doi: https://doi.org/10.1186/s12959-018-0166-4
Jung RG, Motazedian P, Ramirez FD, Simard T, Di Santo P, Visintini S, Faraz MA, Labinaz A, Jung Y, Hibbert B. Association between plasminogen activator inhibitor-1 and cardiovascular events: a systematic review and meta-analysis. Thromb J. 2018 Jun 05;16:12. doi: 10.1186/s12959-018-0166-4. eCollection 2018. PMID: 29991926; PMCID: PMC5987541.
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Thromb J. 2018 Jun 05;16:12. doi: 10.1186/s12959-018-0166-4. eCollection 2018.

Association between plasminogen activator inhibitor-1 and cardiovascular events: a systematic review and meta-analysis.

Thrombosis journal

Richard G Jung, Pouya Motazedian, F Daniel Ramirez, Trevor Simard, Pietro Di Santo, Sarah Visintini, Mohammad Ali Faraz, Alisha Labinaz, Young Jung, Benjamin Hibbert

Affiliations

  1. 1CAPITAL Research Group, University of Ottawa Heart Institute, 40 Ruskin Street, H-4238, Ottawa, ON K1Y 4W7 Canada.
  2. 2Department of Cellular and Molecular Medicine, University of Ottawa, Ottawa, ON Canada.
  3. 3Vascular Biology and Experimental Medicine Laboratory, University of Ottawa Heart Institute, Ottawa, ON Canada.
  4. 4Division of Cardiology, University of Ottawa Heart Institute, Ottawa, ON Canada.
  5. 5School of Epidemiology, Public Health and Preventive Medicine, University of Ottawa, Ottawa, ON Canada.
  6. 6Berkman Library, University of Ottawa Heart Institute, Ottawa, ON Canada.
  7. 7Department of Health Research Methods, Evidence, and Impact, McMaster University, Hamilton, ON Canada.

PMID: 29991926 PMCID: PMC5987541 DOI: 10.1186/s12959-018-0166-4

Abstract

BACKGROUND: Small studies have implicated plasminogen activator inhibitor-1 (PAI-1) as a predictor of cardiovascular events; however, these findings have been inconsistent.We sought out to examine the potential role of PAI-1 as a marker for major adverse cardiovascular events (MACE).

METHODS: We systematically reviewed all indexed studies examining the association between PAI-1 and MACE (defined as death, myocardial infarction, or cerebrovascular accident) or restenosis. EMBASE, Web of Science, Medline, and the Cochrane Library were searched through October 2016 to identify relevant studies, supplemented by letters to authors and review of citations. Studies reporting the results of PAI-1 antigen and/or activity levels in association with MACE in human subjects were included.

RESULTS: Of 5961 articles screened, we identified 38 articles published between 1991 to 2016 that reported PAI-1 levels in 11,557 patients. In studies that examined PAI-1 antigen and activity levels, 15.1% and 29.6% of patients experienced MACE, respectively. Patients with MACE had higher PAI-1 antigen levels with a mean difference of 6.11 ng/mL (95% CI, 3.27-8.96). This finding was similar among patients with and without known coronary artery disease. Comparatively, studies that stratified by PAI-1 activity levels were not associated with MACE. In contrast, studies of coronary restenosis suggest PAI-1 antigen and activity levels are negatively associated with MACE.

CONCLUSIONS: Elevated plasma PAI-1 antigen levels are associated with MACE. Definitive studies are needed to ascertain if PAI-1 acts simply as a marker of risk or if it is indeed a bona fide therapeutic target.

Keywords: Biomarkers; Meta-analysis; Mortality; Myocardial infarction; Plasminogen activator inhibitor-1

Conflict of interest statement

Not applicable.Not applicable.The authors declare that they have no competing interests.Springer Nature remains neutral with regard to jurisdictional claims in published maps and institutional affilia

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