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Vinod KS, Madathil LP, Shetty P, et al. Salivary and Serum Aspartate Aminotransferases and Alanine Aminotransferases in Insulin-Dependent Diabetes Mellitus and Normal Children: A Comparative Study. J Int Soc Prev Community Dent. 2018;8(3):229-234doi: 10.4103/jispcd.JISPCD_60_18.
Vinod, K. S., Madathil, L. P., Shetty, P., Kaur, H., Patel, M., & Gouraha, A. (2018). Salivary and Serum Aspartate Aminotransferases and Alanine Aminotransferases in Insulin-Dependent Diabetes Mellitus and Normal Children: A Comparative Study. Journal of International Society of Preventive & Community Dentistry, 8(3), 229-234. https://doi.org/10.4103/jispcd.JISPCD_60_18
Vinod, K S, et al. "Salivary and Serum Aspartate Aminotransferases and Alanine Aminotransferases in Insulin-Dependent Diabetes Mellitus and Normal Children: A Comparative Study." Journal of International Society of Preventive & Community Dentistry vol. 8,3 (2018): 229-234. doi: https://doi.org/10.4103/jispcd.JISPCD_60_18
Vinod KS, Madathil LP, Shetty P, Kaur H, Patel M, Gouraha A. Salivary and Serum Aspartate Aminotransferases and Alanine Aminotransferases in Insulin-Dependent Diabetes Mellitus and Normal Children: A Comparative Study. J Int Soc Prev Community Dent. 2018 May-Jun;8(3):229-234. doi: 10.4103/jispcd.JISPCD_60_18. Epub 2018 Apr 30. PMID: 29911060; PMCID: PMC5985679.
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J Int Soc Prev Community Dent. 2018 May-Jun;8(3):229-234. doi: 10.4103/jispcd.JISPCD_60_18. Epub 2018 Apr 30.

Salivary and Serum Aspartate Aminotransferases and Alanine Aminotransferases in Insulin-Dependent Diabetes Mellitus and Normal Children: A Comparative Study.

Journal of International Society of Preventive & Community Dentistry

K S Vinod, Lal P Madathil, Pushparaja Shetty, Harsimran Kaur, Mimansha Patel, Abhishek Gouraha

Affiliations

  1. Department of Oral Pathology and Microbiology, Triveni Institute of Dental Sciences, Hospital and Research Centre, Bilaspur, Chhattisgarh, India.
  2. Department of Oral Pathology and Microbiology, Century International Institute of Dental Sciences and Research Centre, Kasargod, Kerala, India.
  3. Department of Oral Pathology and Microbiology, A B Shetty Memorial Institute of Dental Sciences, Mangalore, Karnataka, India.
  4. Department of Pedodontics and Preventive Dentistry, Teerthanker Mahaveer Dental College and Research Centre, Moradabad, Uttar Pradesh, India.

PMID: 29911060 PMCID: PMC5985679 DOI: 10.4103/jispcd.JISPCD_60_18

Abstract

AIMS AND OBJECTIVES: The aim of the study was to estimate and compare aspartate aminotransferases (AST) and alanine aminotransferases (ALT) levels in saliva and serum of insulin-dependent diabetes mellitus (IDDM) and normal children, and the objective was to evaluate the significance of these enzymes in assessing the salivary gland injury in IDDM children.

MATERIALS AND METHODS: The study group comprised of thirty children clinically and biochemically diagnosed for IDDM and thirty healthy children of similar age in the control group. Saliva and serum samples were collected and enzyme assay was performed by optimized ultraviolet test method (according to International Federation of Clinical Chemistry). The values obtained were subjected to statistical analysis using Mann-Whitney U-test for comparison of the variables and Karl-Pearson's coefficient test for correlation. The SPSS 16.0, (SPSS Inc., Chicago, USA) was used for statistical analysis.

RESULTS: Higher values of AST (mean = saliva 91.60 IU/L) and ALT (mean = saliva 94.93 IU/L) were found in the saliva than in serum (AST serum = 15.83 IU/L) (ALT serum = 20.80 IU/L) among the patients and the differences were statistically highly significant (

CONCLUSION: Elevated salivary AST and ALT levels in IDDM patients suggest the injury to salivary glands and could aid as a salivary marker for the involvement of salivary glands in IDDM.

Keywords: Alanine aminotransferase; aspartate aminotransferase; insulin-dependent diabetes mellitus; saliva; serum

Conflict of interest statement

There are no conflicts of interest.

References

  1. Hepatology. 2008 Apr;47(4):1363-70 - PubMed
  2. CMAJ. 2005 Feb 1;172(3):367-79 - PubMed
  3. J Oral Pathol Med. 1993 Feb;22(2):73-6 - PubMed
  4. Aliment Pharmacol Ther. 2017 Sep;46(6):617-627 - PubMed
  5. Diabetes. 2003 Aug;52(8):1967-75 - PubMed
  6. Endocr Connect. 2018 Jan;7(1):R38-R46 - PubMed
  7. Diabetes Care. 2017 Jan;40(Suppl 1):S11-S24 - PubMed
  8. Clin Gastroenterol Hepatol. 2017 Jan;15(1):5-12 - PubMed
  9. Virchows Arch B Cell Pathol Incl Mol Pathol. 1986;51(3):215-25 - PubMed
  10. Med Oral Patol Oral Cir Bucal. 2017 Sep 1;22(5):e586-e594 - PubMed
  11. Diabetes Res Clin Pract. 1997 Dec;38(3):169-72 - PubMed
  12. Clin Biochem Rev. 2013 Nov;34(3):117-30 - PubMed
  13. J Diabetes Res. 2016;2016:4372852 - PubMed
  14. Clin Oral Investig. 2002 Mar;6(1):21-3 - PubMed
  15. Medicine (Baltimore). 2016 Nov;95(47):e5211 - PubMed
  16. Medicine (Baltimore). 2016 Feb;95(6):e2807 - PubMed
  17. J Oral Pathol Med. 2017 Oct;46(9):853-855 - PubMed
  18. Ann Hepatol. 2017 Oct 16;16(6):862-873 - PubMed
  19. Ann Clin Lab Sci. 2016 May;46(3):266-9 - PubMed
  20. Diabetes. 1997 Jun;46(6):941-6 - PubMed
  21. Lancet. 2016 Apr 9;387(10027):1485-6 - PubMed

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