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Le Baut G, Guilloit JM, Leprince V, et al. Oxaliplatin-induced bronchiolitis obliterans organizing pneumonia following hyperthermic intraperitoneal chemotherapy. J Gastrointest Oncol. 2018;9(3):E15-E18doi: 10.21037/jgo.2018.01.01.
Le Baut, G., Guilloit, J. M., Leprince, V., Ollivier, Y., Dubos-Arvis, C., Do, P., Sutter, J., Loge, L., & Gervais, R. (2018). Oxaliplatin-induced bronchiolitis obliterans organizing pneumonia following hyperthermic intraperitoneal chemotherapy. Journal of gastrointestinal oncology, 9(3), E15-E18. https://doi.org/10.21037/jgo.2018.01.01
Le Baut, Guillaume, et al. "Oxaliplatin-induced bronchiolitis obliterans organizing pneumonia following hyperthermic intraperitoneal chemotherapy." Journal of gastrointestinal oncology vol. 9,3 (2018): E15-E18. doi: https://doi.org/10.21037/jgo.2018.01.01
Le Baut G, Guilloit JM, Leprince V, Ollivier Y, Dubos-Arvis C, Do P, Sutter J, Loge L, Gervais R. Oxaliplatin-induced bronchiolitis obliterans organizing pneumonia following hyperthermic intraperitoneal chemotherapy. J Gastrointest Oncol. 2018 Jun;9(3):E15-E18. doi: 10.21037/jgo.2018.01.01. PMID: 29998025; PMCID: PMC6006037.
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J Gastrointest Oncol. 2018 Jun;9(3):E15-E18. doi: 10.21037/jgo.2018.01.01.

Oxaliplatin-induced bronchiolitis obliterans organizing pneumonia following hyperthermic intraperitoneal chemotherapy.

Journal of gastrointestinal oncology

Guillaume Le Baut, Jean-Marc Guilloit, Vincent Leprince, Yann Ollivier, Catherine Dubos-Arvis, Pascal Do, Jasmine Sutter, Ludovic Loge, Radj Gervais

Affiliations

  1. Department of Gastroenterology and Hepatology, Teaching Hospital of Caen, Caen, France.
  2. Department of Medical Oncology, Regional Cancer Centre of Caen, Caen, France.
  3. Department of Immunology, Teaching Hospital of Caen, Caen, France.
  4. Department of Respiratory Medicine, Teaching Hospital of Caen, Caen, France.
  5. Department of Digestive Surgery, Teaching Hospital of Caen, Caen, France.

PMID: 29998025 PMCID: PMC6006037 DOI: 10.21037/jgo.2018.01.01

Abstract

Oxaliplatin given systemically is associated with pneumonitis in less than 1% of cases. This case report describes acute respiratory failure, due to bronchiolitis organising pneumonia, in a patient with colorectal carcinoma being treated with hyperthermic intraperitoneal chemotherapy which included oxaliplatin and CPT-11 (irinotecan). The clinical course, the lack of an identifiable infectious agent and the complete response to corticosteroids suggested a drug-induced cause. After ruling out CPT-11, oxaliplatin was considered to be the causal agent. The unusual feature of this case was that pneumonitis developed after intraperitoneal administration of oxaliplatin. Oxaliplatin-associated respiratory complications can occur whatever route the drug is administered.

Keywords: Bronchiolitis obliterans organizing pneumonia (BOOP); colorectal cancer; hyperthermic intraperitoneal chemotherapy; oxaliplatin

Conflict of interest statement

Conflicts of Interest: The authors have no conflicts of interest to declare.

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