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AboulFotouh K, Allam AA, El-Badry M, et al. Self-emulsifying drug-delivery systems modulate P-glycoprotein activity: role of excipients and formulation aspects. Nanomedicine (Lond). 2018;13(14):1813-1834doi: 10.2217/nnm-2017-0354.
AboulFotouh, K., Allam, A. A., El-Badry, M., & El-Sayed, A. M. (2018). Self-emulsifying drug-delivery systems modulate P-glycoprotein activity: role of excipients and formulation aspects. Nanomedicine (London, England), 13(14), 1813-1834. https://doi.org/10.2217/nnm-2017-0354
AboulFotouh, Khaled, et al. "Self-emulsifying drug-delivery systems modulate P-glycoprotein activity: role of excipients and formulation aspects." Nanomedicine (London, England) vol. 13,14 (2018): 1813-1834. doi: https://doi.org/10.2217/nnm-2017-0354
AboulFotouh K, Allam AA, El-Badry M, El-Sayed AM. Self-emulsifying drug-delivery systems modulate P-glycoprotein activity: role of excipients and formulation aspects. Nanomedicine (Lond). 2018 Jul 01;13(14):1813-1834. doi: 10.2217/nnm-2017-0354. Epub 2018 Aug 03. PMID: 30074420.
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Nanomedicine (Lond). 2018 Jul 01;13(14):1813-1834. doi: 10.2217/nnm-2017-0354. Epub 2018 Aug 03.

Self-emulsifying drug-delivery systems modulate P-glycoprotein activity: role of excipients and formulation aspects.

Nanomedicine (London, England)

Khaled AboulFotouh, Ayat A Allam, Mahmoud El-Badry, Ahmed M El-Sayed

Affiliations

  1. Department of Pharmaceutics, Faculty of Pharmacy, Assiut University, Assiut 71526, Egypt.

PMID: 30074420 DOI: 10.2217/nnm-2017-0354

Abstract

Self-emulsifying drug-delivery systems (SEDDS) have been widely employed to ameliorate the oral bioavailability of P-glycoprotein (P-gp) substrate drugs and to overcome multidrug resistance in cancer cells. However, the role of formulation aspects in the reduced P-gp activity is not fully understood. In this review, we first explore the role of various SEDDS excipients in the reduced P-gp activity with the main emphasis on the effective excipient concentration range for excipient-mediated modulation of P-gp activity and then we discuss the synergistic effect of various formulation aspects on the excipient-mediated modulation of P-gp activity. This review provides an approach to develop a rationally designed SEDDS to overcome P-gp-mediated drug efflux.

Keywords: cancer; effective concentration range; multidrug resistance (MDR)

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