Display options
Cite
Salamat F, Niakan B, Keshtkar A, et al. Subtypes of Benign Breast Disease as a Risk Factor of Breast Cancer: A Systematic Review and Meta Analyses. Iran J Med Sci. 2018;43(4):355-364
Salamat, F., Niakan, B., Keshtkar, A., Rafiei, E., & Zendehdel, M. (2018). Subtypes of Benign Breast Disease as a Risk Factor of Breast Cancer: A Systematic Review and Meta Analyses. Iranian journal of medical sciences, 43(4), 355-364.
Salamat, Fatemeh, et al. "Subtypes of Benign Breast Disease as a Risk Factor of Breast Cancer: A Systematic Review and Meta Analyses." Iranian journal of medical sciences vol. 43,4 (2018): 355-364.
Salamat F, Niakan B, Keshtkar A, Rafiei E, Zendehdel M. Subtypes of Benign Breast Disease as a Risk Factor of Breast Cancer: A Systematic Review and Meta Analyses. Iran J Med Sci. 2018 Jul;43(4):355-364. PMID: 30046203; PMCID: PMC6055208.
Copy Download .nbib Format: NLM
Share it on

Iran J Med Sci. 2018 Jul;43(4):355-364.

Subtypes of Benign Breast Disease as a Risk Factor of Breast Cancer: A Systematic Review and Meta Analyses.

Iranian journal of medical sciences

Fatemeh Salamat, Babak Niakan, Abbasali Keshtkar, Elahe Rafiei, Manoosh Zendehdel

Affiliations

  1. Cancer Research Center, Golestan University of Medical Sciences, Gorgan, Iran.
  2. Department of Health Sciences Education Development, School of Public Health, Tehran University of Medical Sciences, Tehran, Iran.
  3. Razi Clinical Research Development Center, Guilan University of Medical Sciences, Rasht, Iran.
  4. Reproductive Health Research Center, Guilan University of Medical Sciences, Rasht, Iran.

PMID: 30046203 PMCID: PMC6055208

Abstract

BACKGROUND: Researchers suggest that benign breast disease (BBD) is a key risk factor for breast cancer. The present study aimed to determinate the risk level of breast cancer in terms of various BBD subgroups.

METHODS: A meta-analysis was performed to determinate the risk of breast cancer associated with BBD. Observational studies (traditional case-control studies, nested case-control studies, and cohort studies) published from January 2000 to June 2015 were assessed to evaluate the risk of developing breast cancer related to BBD. Various databases such as Medline (PubMed), Web of Science (ISI), Scopus, and Google Scholar were searched. The additional search included the Journal of Breast Cancer Research and Treatment and the Journal of Cancer Research.

RESULTS: Twenty studies out of 21 were used to estimate the risk of developing breast cancer related to proliferative disease without atypia versus non-proliferative disease and the reported risk ranged from 1.04 to 1.83. The reported risk of developing breast cancer related to proliferative disease with atypia versus non-proliferative disease in 21 studies ranged from 1.59 to 4.74. Based on 20 studies, the pooled risk estimates for developing breast cancer related to proliferative disease without atypia versus non-proliferative disease was 1.58 (95% CI: 1.51-1.66). Based on 21 studies, the pooled risk estimates for developing breast cancer related to proliferative disease with atypia versus non-proliferative disease was 3.49 (95% CI: 3.23-3.77).

CONCLUSION: The overall result of this review showed an elevated risk for breast cancer related to BBD subtypes. We propose better strategies for screening recommendations for such women.

Keywords: Breast neoplasms ; Dysplasia, mammary ; Review; Risk factors ; Benign breast disease

References

  1. Breast Cancer Res Treat. 2015 Sep;153(2):397-405 - PubMed
  2. Clin Cancer Res. 2007 Sep 15;13(18 Pt 1):5474-9 - PubMed
  3. Breast Cancer Res Treat. 2013 May;139(1):277-85 - PubMed
  4. Obstet Gynecol Clin North Am. 2013 Sep;40(3):459-73 - PubMed
  5. J Clin Oncol. 2009 Dec 10;27(35):5893-8 - PubMed
  6. J Natl Cancer Inst. 2006 Nov 15;98(22):1600-7 - PubMed
  7. Am J Surg Pathol. 2002 Apr;26(4):421-30 - PubMed
  8. J Natl Cancer Inst. 2004 Apr 21;96(8):616-20 - PubMed
  9. Breast Cancer Res. 2010;12(4):R61 - PubMed
  10. Breast Cancer Res Treat. 2009 Nov;118(1):1-7 - PubMed
  11. Cancer Causes Control. 2010 Jun;21(6):821-8 - PubMed
  12. Curr Med Res Opin. 2015 Feb;31(2):253-62 - PubMed
  13. J Cell Mol Med. 2005 Jan-Mar;9(1):208-21 - PubMed
  14. Cancer Epidemiol. 2010 Feb;34(1):34-9 - PubMed
  15. J Cancer Res Clin Oncol. 2011 Jul;137(7):1053-60 - PubMed
  16. Cancer. 2016 Oct;122(19):2971-8 - PubMed
  17. Cancer. 2015 May 15;121(10):1548-55 - PubMed
  18. Patient Educ Couns. 2009 Jul;76(1):113-9 - PubMed
  19. Cancer. 2009 Apr 1;115(7):1404-11 - PubMed
  20. Breast Cancer Res Treat. 2008 Mar;108(2):167-74 - PubMed
  21. Cancer. 2016 Feb 1;122(3):378-85 - PubMed
  22. Cancer. 2007 Jan 15;109(2):180-7 - PubMed
  23. Cancer Res. 2016 Apr 1;76(7):1926-34 - PubMed
  24. Cancer. 2010 Nov 1;116(21):4944-53 - PubMed
  25. Cancer Med. 2017 Jun;6(6):1482-1489 - PubMed
  26. Breast Cancer Res Treat. 2015 Jan;149(1):237-44 - PubMed
  27. J Public Health (Oxf). 2010 Dec;32(4):565-71 - PubMed
  28. Breast Cancer Res Treat. 2015 Feb;149(3):569-75 - PubMed
  29. Am J Surg Pathol. 2003 Jun;27(6):836-41 - PubMed
  30. Breast J. 2007 Mar-Apr;13(2):115-21 - PubMed
  31. J Natl Cancer Inst. 2013 Jul 17;105(14):1043-9 - PubMed
  32. Cancer. 2006 Sep 15;107(6):1240-7 - PubMed
  33. N Engl J Med. 2005 Jul 21;353(3):229-37 - PubMed
  34. Breast Cancer Res. 2010;12(6):R106 - PubMed
  35. Cancer Prev Res (Phila). 2012 Dec;5(12):1375-80 - PubMed
  36. Am J Surg Pathol. 2006 Jun;30(6):665-72 - PubMed

Publication Types