Display options
Cite
Tetikkurt S, Çelik E, Taş H, et al. Coexistence of adenomyosis, adenocarcinoma, endometrial and myometrial lesions in resected uterine specimens. Mol Clin Oncol. 2018;9(2):231-237doi: 10.3892/mco.2018.1660.
Tetikkurt, S., Çelik, E., Taş, H., Cay, T., Işik, S., & Usta, A. T. (2018). Coexistence of adenomyosis, adenocarcinoma, endometrial and myometrial lesions in resected uterine specimens. Molecular and clinical oncology, 9(2), 231-237. https://doi.org/10.3892/mco.2018.1660
Tetikkurt, Seza, et al. "Coexistence of adenomyosis, adenocarcinoma, endometrial and myometrial lesions in resected uterine specimens." Molecular and clinical oncology vol. 9,2 (2018): 231-237. doi: https://doi.org/10.3892/mco.2018.1660
Tetikkurt S, Çelik E, Taş H, Cay T, Işik S, Usta AT. Coexistence of adenomyosis, adenocarcinoma, endometrial and myometrial lesions in resected uterine specimens. Mol Clin Oncol. 2018 Aug;9(2):231-237. doi: 10.3892/mco.2018.1660. Epub 2018 Jun 18. PMID: 30101029; PMCID: PMC6083418.
Copy Download .nbib Format: NLM
Share it on

Mol Clin Oncol. 2018 Aug;9(2):231-237. doi: 10.3892/mco.2018.1660. Epub 2018 Jun 18.

Coexistence of adenomyosis, adenocarcinoma, endometrial and myometrial lesions in resected uterine specimens.

Molecular and clinical oncology

Seza Tetikkurt, Elif Çelik, Hazal Taş, Tuğçe Cay, Selman Işik, Abdullah Taner Usta

Affiliations

  1. Department of Pathology, Ba?c?lar Training and Research Hospital, University of Health Sciences, Istanbul 34200, Turkey.
  2. Department of Obstetrics and Gynecology, Ba?c?lar Training and Research Hospital, University of Health Sciences, Istanbul 34200, Turkey.
  3. Department of Obstetrics and Gynecology, Ac?badem University, Istanbul 34718, Turkey.

PMID: 30101029 PMCID: PMC6083418 DOI: 10.3892/mco.2018.1660

Abstract

The present study was conducted to identify endometrial and myometrial lesions coexisting with adenomyosis, and to evaluate the clinicopathological characteristics of endometrial adenocarcinomas associated with adenomyosis. A retrospective analysis of the resected uterine specimens of 319 patients with adenomyosis admitted between January 1, 2014 and August 1, 2017 was performed. The endometrial and myometrial lesions coexisting with adenomyosis were evaluated. The clinicopathological prognostic factors, including tumor grade, myometrial invasion, lymphovascular space involvement, lymph node invasion, pathological stage and recurrence, were analysed. For data analysis, the Chi-squared test was used and a P-value of <0.05 was considered to indicate statistically significant differences. The mean age of the patients was 52.1 years. A total of 32 patients had endometrial carcinoma associated with adenomyosis. In addition to endometrioid adenocarcinoma of different grades, rare clear cell carcinoma cases were also observed. Two cases of malignant mesenchymal tumors (one low-grade endometrial stromal sarcoma and one leiomyosarcoma) were also diagnosed. Therefore, patients presenting with abnormal uterine bleeding should undergo thorough evaluation for the presence of adenomyosis and/or leiomyoma(s). Although the cases of endometrial adenocarcinoma associated with adenomyosis generally had a good prognostic outcome, there were also rare cases of patients with agressive tumor morphology. The inflammatory and tissue response arising around the foci of adenomyosis generate a preventive mechanism against the invasion of adenocarcinomas coexisting with adenomyosis. This response is likely the primary mechanism underlying the good clinical course of these tumors. Therefore, the presence of adenomyosis may be an important factor for the determination of prognosis.

Keywords: adenomyosis; endometrial adenocarcinoma; endometrioid adenocarcinoma; leiomyoma; prognosis

References

  1. Eur J Obstet Gynecol Reprod Biol. 2009 Apr;143(2):103-6 - PubMed
  2. Best Pract Res Clin Obstet Gynaecol. 2006 Aug;20(4):523-46 - PubMed
  3. Clin Exp Obstet Gynecol. 2007;34(3):163-7 - PubMed
  4. Hum Pathol. 2004 Jun;35(6):649-62 - PubMed
  5. Environ Health Perspect. 2003 Jun;111(8):1037-54 - PubMed
  6. Arch Gynecol Obstet. 2009 Oct;280(4):529-38 - PubMed
  7. Theriogenology. 2013 Jan 1;79(1):165-72 - PubMed
  8. Ann Diagn Pathol. 2007 Aug;11(4):252-7 - PubMed
  9. Gynecol Oncol. 1990 Jun;37(3):401-7 - PubMed
  10. Oncol Rep. 2013 Mar;29(3):861-7 - PubMed
  11. Kathmandu Univ Med J (KUMJ). 2012 Jan-Mar;10(37):53-6 - PubMed
  12. Int J Gynecol Pathol. 2007 Jul;26(3):278-83 - PubMed
  13. Horm Mol Biol Clin Investig. 2011 Mar 1;5(2):125-42 - PubMed
  14. Am J Obstet Gynecol. 1993 Sep;169(3):734-8 - PubMed
  15. Am J Obstet Gynecol. 1972 Mar;112(5):583-93 - PubMed
  16. Hum Reprod. 2008 Dec;23(12):2692-700 - PubMed
  17. Gynecol Oncol. 1995 Jul;58(1):86-91 - PubMed
  18. Mol Hum Reprod. 2001 Nov;7(11):1085-91 - PubMed
  19. Reprod Biomed Online. 2008 Aug;17(2):244-8 - PubMed
  20. Oncol Lett. 2016 Feb;11(2):1213-1219 - PubMed
  21. Hum Reprod. 1997 Jun;12(6):1275-9 - PubMed
  22. Biomed Res Int. 2017;2017:2518396 - PubMed
  23. Am J Obstet Gynecol. 1962 Dec 15;84:1820-9 - PubMed
  24. Nihon Sanka Fujinka Gakkai Zasshi. 1989 Nov;41(11):1849-50 - PubMed
  25. Am J Obstet Gynecol. 1971 May 15;110(2):275-84 - PubMed
  26. Obstet Gynecol Surv. 2000 Jun;55(6):390-400 - PubMed
  27. Hum Reprod. 2001 Nov;16(11):2418-21 - PubMed
  28. Cancer Imaging. 2008 Jun 30;8:135-45 - PubMed
  29. Obstet Gynecol Clin North Am. 1989 Mar;16(1):221-35 - PubMed
  30. J Epidemiol Biostat. 2001;6(1):47-86 - PubMed
  31. Am J Physiol. 1999 Jun;276(6 Pt 1):E1112-8 - PubMed
  32. Hum Reprod. 1995 May;10(5):1160-2 - PubMed
  33. Eur J Gynaecol Oncol. 2011;32(2):182-4 - PubMed
  34. CA Cancer J Clin. 2015 Jan-Feb;65(1):5-29 - PubMed
  35. Fertil Steril. 2009 Jan;91(1):201-6 - PubMed
  36. Geburtshilfe Frauenheilkd. 2013 Sep;73(9):924-931 - PubMed
  37. Am J Obstet Gynecol. 1980 Dec 1;138(7 Pt 1):827-32 - PubMed
  38. Reproduction. 2001 Apr;121(4):581-6 - PubMed
  39. Cancer Detect Prev. 2004;28(2):94-8 - PubMed
  40. Arch Gynecol Obstet. 2013 Dec;288(6):1329-39 - PubMed
  41. Acta Endocrinol (Copenh). 1989 Aug;121(2):259-64 - PubMed
  42. Gynecol Oncol. 1993 May;49(2):197-201 - PubMed
  43. Histopathology. 2000 Oct;37(4):340-6 - PubMed
  44. Nepal Med Coll J. 2012 Sep;14(3):176-9 - PubMed
  45. Mod Pathol. 1993 Jan;6(1):94-106 - PubMed
  46. J Clin Pathol. 1990 Oct;43(10):817-9 - PubMed
  47. Gynecol Oncol. 1984 Jan;17(1):32-40 - PubMed

Publication Types