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Bischoff-Ferrari HA, Orav EJ, Egli A, et al. Recovery after unilateral knee replacement due to severe osteoarthritis and progression in the contralateral knee: a randomised clinical trial comparing daily 2000 IU versus 800 IU vitamin D. RMD Open. 2018;4(2):e000678doi: 10.1136/rmdopen-2018-000678.
Bischoff-Ferrari, H. A., Orav, E. J., Egli, A., Dawson-Hughes, B., Fischer, K., Staehelin, H. B., Rizzoli, R., Hodler, J., von Eckardstein, A., Freystaetter, G., Meyer, U., Guggi, T., Burckhardt, P., Schietzel, S., Chocano-Bedoya, P., Theiler, R., Willett, W. C., & Felson, D. (2018). Recovery after unilateral knee replacement due to severe osteoarthritis and progression in the contralateral knee: a randomised clinical trial comparing daily 2000 IU versus 800 IU vitamin D. RMD open, 4(2), e000678. https://doi.org/10.1136/rmdopen-2018-000678
Bischoff-Ferrari, Heike A, et al. "Recovery after unilateral knee replacement due to severe osteoarthritis and progression in the contralateral knee: a randomised clinical trial comparing daily 2000 IU versus 800 IU vitamin D." RMD open vol. 4,2 (2018): e000678. doi: https://doi.org/10.1136/rmdopen-2018-000678
Bischoff-Ferrari HA, Orav EJ, Egli A, Dawson-Hughes B, Fischer K, Staehelin HB, Rizzoli R, Hodler J, von Eckardstein A, Freystaetter G, Meyer U, Guggi T, Burckhardt P, Schietzel S, Chocano-Bedoya P, Theiler R, Willett WC, Felson D. Recovery after unilateral knee replacement due to severe osteoarthritis and progression in the contralateral knee: a randomised clinical trial comparing daily 2000 IU versus 800 IU vitamin D. RMD Open. 2018 Jul 09;4(2):e000678. doi: 10.1136/rmdopen-2018-000678. eCollection 2018. PMID: 30018805; PMCID: PMC6045766.
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RMD Open. 2018 Jul 09;4(2):e000678. doi: 10.1136/rmdopen-2018-000678. eCollection 2018.

Recovery after unilateral knee replacement due to severe osteoarthritis and progression in the contralateral knee: a randomised clinical trial comparing daily 2000 IU versus 800 IU vitamin D.

RMD open

Heike A Bischoff-Ferrari, E John Orav, Andreas Egli, Bess Dawson-Hughes, Karina Fischer, Hannes B Staehelin, Rene Rizzoli, Juerg Hodler, Arnold von Eckardstein, Gregor Freystaetter, Ursina Meyer, Thomas Guggi, Peter Burckhardt, Simeon Schietzel, Patricia Chocano-Bedoya, Robert Theiler, Walter C Willett, David Felson

Affiliations

  1. Department of Geriatrics and Aging Research, University Hospital Zurich, University of Zurich, Zurich, Switzerland.
  2. Center on Aging and Mobility, University of Zurich, Zurich, Switzerland.
  3. University Clinic for Acute Geriatric Care, City Hospital Waid, Zurich, Switzerland.
  4. Department of Biostatistics, Harvard School of Public Health, Boston, Massachusetts, USA.
  5. Jean Mayer USDA Human Nutrition Research Center on Aging, Tufts University, Boston, Massachusetts, USA.
  6. Department of Geriatrics, University of Basel, Basel, Switzerland.
  7. Division of Bone Diseases, Geneva University Hospitals, Geneva, Switzerland.
  8. Institute of Radiology, University Hospital Zurich, Zurich, Switzerland.
  9. Institute of Clinical Chemistry, University Hospital Zurich, Zurich, Switzerland.
  10. Department of Orthopaedic Surgery, Schulthess Clinic, Zurich, Switzerland.
  11. Department of Endocrinology, CHUV, Lausanne, Switzerland.
  12. Department of Nutrition, Harvard School of Public Health, Boston, Massachusetts, USA.
  13. Clinical Epidemiology Research and Training Unit, Boston University, Boston, Massachusetts, USA.

PMID: 30018805 PMCID: PMC6045766 DOI: 10.1136/rmdopen-2018-000678

Abstract

OBJECTIVE: To test whether daily high-dose vitamin D improves recovery after unilateral total knee replacement.

METHODS: Data come from a 24-month randomised, double-blind clinical trial. Adults aged 60 and older undergoing unilateral joint replacement due to severe knee osteoarthritis were 6-8 weeks after surgery randomly assigned to receive daily high-dose (2000 IU) or standard-dose (800 IU) vitamin D

RESULTS: We recruited 273 participants, 137 were randomised to receive 2000 IU and 136 were randomised to receive 800 IU vitamin D per day. 2000 IU vitamin D increased 25-hydroxyvitamin D levels to 45.6 ng/mL and 800 IU vitamin D to 37.1 ng/mL at month 24 (p<0.0001). While symptoms improved significantly in the operated knee and remained stable in the contralateral knee over time, none of the primary or secondary endpoints differed by treatment group over time. The rate of falls over 24 months was 1.05 with 2000 IU and 1.07 with 800 IU (p=0.84). 30.5% of participants in the 2000 IU and 31.3% of participants in the 800 IU group had radiographic progression in the contralateral knee over 24 months (p=0.88).

CONCLUSIONS: Our findings suggest that a 24-month treatment with daily 2000 IU vitamin D did not show greater benefits or harm than a daily standard dose of 800 IU among older adults undergoing unilateral total knee replacement.

Keywords: knee osteoarthritis; orthopaedicsurgery; rehabilitation

Conflict of interest statement

Competing interests: None declared.

References

  1. Arthritis Rheum. 1999 Jul;42(7):1378-85 - PubMed
  2. J Rheumatol. 2008 Oct;35(10):2047-54 - PubMed
  3. Semin Arthritis Rheum. 2016 Apr;45(5):539-46 - PubMed
  4. Am J Med. 2003 Feb 1;114(2):93-8 - PubMed
  5. J Clin Endocrinol Metab. 2013 Dec;98(12):E1927-35 - PubMed
  6. J Bone Joint Surg Am. 2013 Jun 5;95(11):989-93 - PubMed
  7. Biochim Biophys Acta. 1987 Oct 22;931(1):26-32 - PubMed
  8. J Mol Histol. 2010 Apr;41(2-3):137-42 - PubMed
  9. Arthritis Care Res (Hoboken). 2014 Sep;66(9):1328-36 - PubMed
  10. Best Pract Res Clin Rheumatol. 2006 Feb;20(1):3-25 - PubMed
  11. N Engl J Med. 1990 Sep 13;323(11):725-31 - PubMed
  12. J Am Geriatr Soc. 2011 Dec;59(12):2291-300 - PubMed
  13. Ann Intern Med. 1996 Sep 1;125(5):353-9 - PubMed
  14. Arthritis Rheum. 1998 Aug;41(8):1343-55 - PubMed
  15. N Engl J Med. 1990 Sep 20;323(12):801-7 - PubMed
  16. Arch Intern Med. 2006 Feb 27;166(4):424-30 - PubMed
  17. BMJ. 2009 Oct 01;339:b3692 - PubMed
  18. J Bone Miner Res. 2000 Jun;15(6):1113-8 - PubMed
  19. Rheumatology (Oxford). 2013 Jul;52(7):1323-34 - PubMed
  20. Arthritis Rheum. 2006 Aug 15;55(4):610-5 - PubMed
  21. Arthritis Rheum. 2004 Oct 15;51(5):829-35 - PubMed
  22. Ann Intern Med. 2012 Mar 20;156(6):425-37 - PubMed
  23. Clin Orthop Relat Res. 2013 Nov;471(11):3556-62 - PubMed
  24. J Bone Miner Res. 2004 Feb;19(2):265-9 - PubMed
  25. JAMA. 2013 Jan 9;309(2):155-62 - PubMed
  26. J Am Geriatr Soc. 1993 Mar;41(3):297-308 - PubMed
  27. Am J Public Health. 1994 Mar;84(3):351-8 - PubMed
  28. J Nurs Meas. 2001 Winter;9(3):275-90 - PubMed
  29. J Rheumatol. 2005 Jun;32(6):1133-5 - PubMed
  30. Osteoarthritis Cartilage. 2016 Nov;24(11):1858-1866 - PubMed
  31. Arch Intern Med. 2010 May 10;170(9):813-20 - PubMed
  32. Ann Rheum Dis. 2003 Oct;62(10):923-30 - PubMed
  33. Steroids. 2001 Mar-May;66(3-5):363-74 - PubMed
  34. Clin Chem. 2005 Sep;51(9):1683-90 - PubMed
  35. JAMA. 2016 Mar 8;315(10):1005-13 - PubMed
  36. Arthritis Rheum. 2005 Dec 15;53(6):821-6 - PubMed
  37. Arthritis Care Res (Hoboken). 2016 Nov;68(11):1640-1646 - PubMed
  38. J Clin Epidemiol. 2011 Feb;64(2):182-90 - PubMed
  39. Ann Rheum Dis. 1998 Dec;57(12):717-23 - PubMed
  40. J Cell Biol. 1999 Nov 29;147(5):1097-108 - PubMed
  41. Am J Clin Pathol. 2006 Jun;125(6):914-20 - PubMed
  42. Ann Intern Med. 2000 Nov 7;133(9):726-37 - PubMed
  43. J Steroid Biochem Mol Biol. 2017 Oct;173:180-184 - PubMed
  44. Arch Intern Med. 2009 Mar 23;169(6):551-61 - PubMed
  45. N Engl J Med. 2012 Jul 5;367(1):40-9 - PubMed

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