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Wanat M, Anthierens S, Butler CC, et al. Patient and Prescriber Views of Penicillin Allergy Testing and Subsequent Antibiotic Use: A Rapid Review. Antibiotics (Basel). 2018;7(3)doi: 10.3390/antibiotics7030071.
Wanat, M., Anthierens, S., Butler, C. C., Wright, J. M., Dracup, N., Pavitt, S. H., Sandoe, J. A. T., & Tonkin-Crine, S. (2018). Patient and Prescriber Views of Penicillin Allergy Testing and Subsequent Antibiotic Use: A Rapid Review. Antibiotics (Basel, Switzerland), 7(3), . https://doi.org/10.3390/antibiotics7030071
Wanat, Marta, et al. "Patient and Prescriber Views of Penicillin Allergy Testing and Subsequent Antibiotic Use: A Rapid Review." Antibiotics (Basel, Switzerland) vol. 7,3 (2018). doi: https://doi.org/10.3390/antibiotics7030071
Wanat M, Anthierens S, Butler CC, Wright JM, Dracup N, Pavitt SH, Sandoe JAT, Tonkin-Crine S. Patient and Prescriber Views of Penicillin Allergy Testing and Subsequent Antibiotic Use: A Rapid Review. Antibiotics (Basel). 2018 Aug 06;7(3). doi: 10.3390/antibiotics7030071. PMID: 30082596; PMCID: PMC6164736.
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Antibiotics (Basel). 2018 Aug 06;7(3). doi: 10.3390/antibiotics7030071.

Patient and Prescriber Views of Penicillin Allergy Testing and Subsequent Antibiotic Use: A Rapid Review.

Antibiotics (Basel, Switzerland)

Marta Wanat, Sibyl Anthierens, Christopher C Butler, Judy M Wright, Naila Dracup, Sue H Pavitt, Jonathan A T Sandoe, Sarah Tonkin-Crine

Affiliations

  1. Nuffield Department of Primary Care Health Sciences, University of Oxford, Radcliffe Observatory Quarter, Woodstock Road, Oxford OX2 6GG, UK. [email protected].
  2. Department of Primary and Interdisciplinary care, University of Antwerp, Campus "Drie Eiken", Gebouw R, Universiteitsplein 1, B-2610 WILRIJK Antwerpen, Belgium. [email protected].
  3. Nuffield Department of Primary Care Health Sciences, University of Oxford, Radcliffe Observatory Quarter, Woodstock Road, Oxford OX2 6GG, UK. [email protected].
  4. Leeds Institute of Health Sciences', Faculty of Medicine and Health, University of Leeds, Worsley Building, Clarendon Way, Leeds LS2 9LU, UK. [email protected].
  5. Leeds Institute of Health Sciences', Faculty of Medicine and Health, University of Leeds, Worsley Building, Clarendon Way, Leeds LS2 9LU, UK. [email protected].
  6. Dental Translational and Clinical Research Unit, Faculty of Medicine and Health, University of Leeds, Worsley Building, Clarendon Way, Leeds LS2 9LU, UK. [email protected].
  7. Healthcare Associated Infection Group, University of Leeds and Leeds Teaching Hospitals NHS Trust, Leeds LS13EX, UK. [email protected].
  8. Nuffield Department of Primary Care Health Sciences, University of Oxford, Radcliffe Observatory Quarter, Woodstock Road, Oxford OX2 6GG, UK. [email protected].
  9. NIHR Health Protection Research Unit in Healthcare Associated Infections and Antimicrobial Resistance, University of Oxford, Wellington Square, Oxford OX1 2JD, UK. [email protected].

PMID: 30082596 PMCID: PMC6164736 DOI: 10.3390/antibiotics7030071

Abstract

About 10% of U.K. patients believe that they are allergic to penicillin and have a "penicillin allergy label" in their primary care health record. However, around 90% of these patients may be mislabelled. Removing incorrect penicillin allergy labels can help to reduce unnecessary broad-spectrum antibiotic use. A rapid review was undertaken of papers exploring patient and/or clinician views and experiences of penicillin allergy testing (PAT) services and the influences on antibiotic prescribing behaviour in the context of penicillin allergy. We reviewed English-language publications published up to November 2017. Limited evidence on patients' experiences of PAT highlighted advantages to testing as well as a number of concerns. Clinicians reported uncertainty about referral criteria for PAT. Following PAT and a negative result, a number of clinicians and patients remained reluctant to prescribe and consume penicillins. This appeared to reflect a lack of confidence in the test result and fear of subsequent reactions to penicillins. The findings suggest lack of awareness and knowledge of PAT services by both clinicians and patients. In order to ensure correct penicillin allergy diagnosis, clinicians and patients need to be supported to use PAT services and equipped with the skills to use penicillins appropriately following a negative allergy test result.

Keywords: antibiotic resistance; antibiotic stewardship; penicillin allergy; prescribing

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