Display options
Cite
Elsamanoudy AZ, Mohamed Neamat-Allah MA, Hisham Mohammad FA, et al. The role of nutrition related genes and nutrigenetics in understanding the pathogenesis of cancer. J Microsc Ultrastruct. 2016;4(3):115-122doi: 10.1016/j.jmau.2016.02.002.
Elsamanoudy, A. Z., Mohamed Neamat-Allah, M. A., Hisham Mohammad, F. A., Hassanien, M., & Nada, H. A. (2016). The role of nutrition related genes and nutrigenetics in understanding the pathogenesis of cancer. Journal of microscopy and ultrastructure, 4(3), 115-122. https://doi.org/10.1016/j.jmau.2016.02.002
Elsamanoudy, Ayman Zaky, et al. "The role of nutrition related genes and nutrigenetics in understanding the pathogenesis of cancer." Journal of microscopy and ultrastructure vol. 4,3 (2016): 115-122. doi: https://doi.org/10.1016/j.jmau.2016.02.002
Elsamanoudy AZ, Mohamed Neamat-Allah MA, Hisham Mohammad FA, Hassanien M, Nada HA. The role of nutrition related genes and nutrigenetics in understanding the pathogenesis of cancer. J Microsc Ultrastruct. 2016 Jul-Sep;4(3):115-122. doi: 10.1016/j.jmau.2016.02.002. Epub 2016 Mar 08. PMID: 30023217; PMCID: PMC6014201.
Copy Download .nbib Format: NLM
Share it on

J Microsc Ultrastruct. 2016 Jul-Sep;4(3):115-122. doi: 10.1016/j.jmau.2016.02.002. Epub 2016 Mar 08.

The role of nutrition related genes and nutrigenetics in understanding the pathogenesis of cancer.

Journal of microscopy and ultrastructure

Ayman Zaky Elsamanoudy, Moustafa Ahmed Mohamed Neamat-Allah, Fatma Azzahra' Hisham Mohammad, Mohammed Hassanien, Hoda Ahmed Nada

Affiliations

  1. Clinical Biochemistry, Faculty of Medicine, King Abdulaziz University, Jeddah, Saudi Arabia.
  2. Medical Biochemistry and Molecular Biology, Faculty of Medicine, Mansoura University, Mansoura, Egypt.
  3. Medical Biochemistry Department, Faculty of Medicine, Tanta University, Tanta, Egypt.

PMID: 30023217 PMCID: PMC6014201 DOI: 10.1016/j.jmau.2016.02.002

Abstract

Nutrition has a predominant and recognizable role in health management. Nutrigenetics is the science that identifies and characterizes gene variants associated with differential response to nutrients and relating this variation to variable disease states especially cancer. This arises from the epidemiological fact that cancer accounts for a high proportion of total morbidity and mortality in adults throughout the world. There is much evidence to support that genetic factors play a key role in the development of cancer; these genetic factors such as DNA instability and gene alterations are affected by nutrition. Nutrition may also lead to aberrant DNA methylation, which in turn contributes to carcinogenesis. The aim of this work is to clarify the basic knowledge about the vital role of nutrition-related genes in various disease states, especially cancer, and to identify nutrigenetics as a new concept that could highlight the relation between nutrition and gene expression. This may help to understand the mechanism and pathogenesis of cancer. The cause of cancer is a complex interplay mechanism of genetic and environmental factors. Dietary nutrient intake is an essential environmental factor and there is a marked variation in cancer development with the same dietary intake between individuals. This could be explained by the variation in their genetic polymorphisms, which leads to emergence of the concept of nutrigenomics and nutrigenetics.

Keywords: cancer; nutrigenetics; pathogenesis

References

  1. Exp Biol Med (Maywood). 2010 Jul;235(7):785-95 - PubMed
  2. J Med Food. 2007 Jun;10(2):239-43 - PubMed
  3. Prev Nutr Food Sci. 2015 Mar;20(1):1-7 - PubMed
  4. Am J Clin Nutr. 2005 Jan;81(1 Suppl):230S-242S - PubMed
  5. Biomed Pharmacother. 2006 Nov;60(9):508-19 - PubMed
  6. Nutrients. 2014 Nov 21;6(11):5338-69 - PubMed
  7. Prostate. 2000 Dec 1;45(4):304-14 - PubMed
  8. Cancer Res. 2004 Aug 15;64(16):5767-74 - PubMed
  9. Nutr Cancer. 2006;56(2):216-24 - PubMed
  10. Semin Cancer Biol. 2007 Oct;17(5):347-53 - PubMed
  11. J Am Diet Assoc. 2005 Apr;105(4):589-98 - PubMed
  12. Environ Mol Mutagen. 2008 Jan;49(1):4-8 - PubMed
  13. Ann N Y Acad Sci. 2003 Mar;983:197-207 - PubMed
  14. Am J Clin Nutr. 2011 Jun;93(6):1365-72 - PubMed
  15. Proc Natl Acad Sci U S A. 2008 Oct 21;105(42):16230-5 - PubMed
  16. Nat Rev Genet. 2000 Oct;1(1):11-9 - PubMed
  17. Proc Nutr Soc. 2008 May;67(2):146-56 - PubMed
  18. J Clin Invest. 2007 Jul;117(7):1866-75 - PubMed
  19. Curr Cancer Drug Targets. 2007 Aug;7(5):416-24 - PubMed
  20. Proc Nutr Soc. 2004 Feb;63(1):167-72 - PubMed
  21. Am J Clin Nutr. 2009 May;89(5):1565S-1571S - PubMed
  22. Am J Clin Nutr. 2009 May;89(5):1541S-1542S - PubMed
  23. Food Chem Toxicol. 2008 Apr;46(4):1365-70 - PubMed
  24. J Nutrigenet Nutrigenomics. 2013;6(1):16-31 - PubMed
  25. J Nutr. 2003 Sep;133(9):2901-6 - PubMed
  26. Am J Clin Nutr. 2009 May;89(5):1543S-1548S - PubMed
  27. Circ Cardiovasc Genet. 2009 Dec;2(6):637-51 - PubMed
  28. Forum Nutr. 2007;60:25-30 - PubMed
  29. Dev Neurobiol. 2008 Jan;68(1):18-30 - PubMed
  30. Br J Nutr. 2009 Feb;101(3):307-16 - PubMed
  31. J Nutrigenet Nutrigenomics. 2011;4(1):25-35 - PubMed
  32. Lung Cancer. 2009 Aug;65(2):129-37 - PubMed
  33. Nutr Rev. 2007 Aug;65(8 Pt 2):S121-3 - PubMed
  34. Curr Cancer Drug Targets. 2007 Aug;7(5):438-46 - PubMed
  35. Nutrition. 2004 Jan;20(1):26-31 - PubMed
  36. Am J Clin Nutr. 2009 May;89(5):1572S-1587S - PubMed
  37. Nutr Rev. 2007 Aug;65(8 Pt 2):S134-7 - PubMed
  38. J Clin Oncol. 2006 Oct 1;24(28):4534-8 - PubMed
  39. J Steroid Biochem Mol Biol. 2008 Feb;108(3-5):181-5 - PubMed
  40. Public Health Nutr. 2004 Jun;7(4):549-56 - PubMed
  41. Front Biosci. 2008 Jan 01;13:2191-202 - PubMed
  42. Genes Nutr. 2008 Jul;3(2):41-9 - PubMed
  43. IUBMB Life. 2008 May;60(5):341-4 - PubMed

Publication Types