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Mousa SA, Glinsky GV, Lin HY, et al. Contributions of Thyroid Hormone to Cancer Metastasis. Biomedicines. 2018;6(3)doi: 10.3390/biomedicines6030089.
Mousa, S. A., Glinsky, G. V., Lin, H. Y., Ashur-Fabian, O., Hercbergs, A., Keating, K. A., & Davis, P. J. (2018). Contributions of Thyroid Hormone to Cancer Metastasis. Biomedicines, 6(3), . https://doi.org/10.3390/biomedicines6030089
Mousa, Shaker A, et al. "Contributions of Thyroid Hormone to Cancer Metastasis." Biomedicines vol. 6,3 (2018). doi: https://doi.org/10.3390/biomedicines6030089
Mousa SA, Glinsky GV, Lin HY, Ashur-Fabian O, Hercbergs A, Keating KA, Davis PJ. Contributions of Thyroid Hormone to Cancer Metastasis. Biomedicines. 2018 Aug 22;6(3). doi: 10.3390/biomedicines6030089. PMID: 30135398; PMCID: PMC6165185.
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Biomedicines. 2018 Aug 22;6(3). doi: 10.3390/biomedicines6030089.

Contributions of Thyroid Hormone to Cancer Metastasis.

Biomedicines

Shaker A Mousa, Gennadi V Glinsky, Hung-Yun Lin, Osnat Ashur-Fabian, Aleck Hercbergs, Kelly A Keating, Paul J Davis

Affiliations

  1. Pharmaceutical Research Institute, Albany College of Pharmacy and Health Sciences, Rensselaer, NY 12144, USA. [email protected].
  2. Institute of Engineering in Medicine, University of California, San Diego, CA 92093, USA. [email protected].
  3. Pharmaceutical Research Institute, Albany College of Pharmacy and Health Sciences, Rensselaer, NY 12144, USA. [email protected].
  4. PhD Program for Cancer Molecular Biology and Drug Discovery, College of Medical Science and Technology, Taipei Medical University, Taipei 11031, Taiwan. [email protected].
  5. Taipei Cancer Center, Taipei Medical University, Taipei 11031 Taiwan. [email protected].
  6. Traditional Herbal Medicine Research Center of Taipei Medical University Hospital, Taipei 11031, Taiwan. [email protected].
  7. TMU Research Center of Cancer Translational Medicine, Taipei Medical University, Taipei 11031, Taiwan. [email protected].
  8. Department of Human Molecular Genetics and Biochemistry, Tel Aviv University, Tel Aviv 69978, Israel. [email protected].
  9. Department of Radiation Oncology, Cleveland Clinic, Cleveland, OH 44195, USA. [email protected].
  10. Pharmaceutical Research Institute, Albany College of Pharmacy and Health Sciences, Rensselaer, NY 12144, USA. [email protected].
  11. Pharmaceutical Research Institute, Albany College of Pharmacy and Health Sciences, Rensselaer, NY 12144, USA. [email protected].
  12. Department of Medicine, Albany Medical College, Albany, NY 12208, USA. [email protected].

PMID: 30135398 PMCID: PMC6165185 DOI: 10.3390/biomedicines6030089

Abstract

Acting at a cell surface receptor on the extracellular domain of integrin αvβ3, thyroid hormone analogues regulate downstream the expression of a large panel of genes relevant to cancer cell proliferation, to cancer cell survival pathways, and to tumor-linked angiogenesis. Because αvβ3 is involved in the cancer cell metastatic process, we examine here the possibility that thyroid hormone as l-thyroxine (T4) and the thyroid hormone antagonist, tetraiodothyroacetic acid (tetrac), may respectively promote and inhibit metastasis. Actions of T4 and tetrac that are relevant to cancer metastasis include the multitude of synergistic effects on molecular levels such as expression of matrix metalloproteinase genes, angiogenesis support genes, receptor tyrosine kinase (

Keywords: T4; angiogenesis; cancer; cancer cell genes; epithelial-to-mesenchymal transition (EMT); integrin αvβ3; l-thyroxine; matrix metalloproteinases; metastasis; tetrac; thyroid hormone

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