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Omotobara-Yabe T, Kuga S, Takeguchi M, et al. Vitamin D deficiency associated with dilated cardiomyopathy in early infancy caused by maternal cholestasis. Clin Pediatr Endocrinol. 2018;27(3):187-192doi: 10.1297/cpe.27.187.
Omotobara-Yabe, T., Kuga, S., Takeguchi, M., & Ihara, K. (2018). Vitamin D deficiency associated with dilated cardiomyopathy in early infancy caused by maternal cholestasis. Clinical pediatric endocrinology : case reports and clinical investigations : official journal of the Japanese Society for Pediatric Endocrinology, 27(3), 187-192. https://doi.org/10.1297/cpe.27.187
Omotobara-Yabe, Tomona, et al. "Vitamin D deficiency associated with dilated cardiomyopathy in early infancy caused by maternal cholestasis." Clinical pediatric endocrinology : case reports and clinical investigations : official journal of the Japanese Society for Pediatric Endocrinology vol. 27,3 (2018): 187-192. doi: https://doi.org/10.1297/cpe.27.187
Omotobara-Yabe T, Kuga S, Takeguchi M, Ihara K. Vitamin D deficiency associated with dilated cardiomyopathy in early infancy caused by maternal cholestasis. Clin Pediatr Endocrinol. 2018;27(3):187-192. doi: 10.1297/cpe.27.187. Epub 2018 Jul 31. PMID: 30083036; PMCID: PMC6073062.
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Clin Pediatr Endocrinol. 2018;27(3):187-192. doi: 10.1297/cpe.27.187. Epub 2018 Jul 31.

Vitamin D deficiency associated with dilated cardiomyopathy in early infancy caused by maternal cholestasis.

Clinical pediatric endocrinology : case reports and clinical investigations : official journal of the Japanese Society for Pediatric Endocrinology

Tomona Omotobara-Yabe, Shuji Kuga, Masahiro Takeguchi, Kenji Ihara

Affiliations

  1. Department of Pediatrics, Oita University Faculty of Medicine, Oita, Japan.

PMID: 30083036 PMCID: PMC6073062 DOI: 10.1297/cpe.27.187

Abstract

Breast feeding is known to be a major cause of vitamin D deficiency in infants because the content of vitamin D in breast milk is significantly lower than that in formula. We report a case of a 1-mo-old boy who developed hypocalcemic seizures and dilated cardiomyopathy caused by vitamin D deficiency despite being fed a sufficient amount of regular formula. The cause of vitamin D deficiency in this case was maternal vitamin deficiency due to severe hyperemesis and insufficient sunlight exposure, induced mainly by the malabsorption of fat-soluble vitamins caused by maternal cholestasis. We should carefully consider maternal conditions during pregnancy and the postpartum period to detect and prevent vitamin D deficiency in the fetus and infant.

Keywords: cholestasis; dilated cardiomyopathy; formula; hypocalcemia; vitamin D deficiency

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