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Choi J, Kim JH, Jang JW, et al. Decellularized sciatic nerve matrix as a biodegradable conduit for peripheral nerve regeneration. Neural Regen Res. 2018;13(10):1796-1803doi: 10.4103/1673-5374.237126.
Choi, J., Kim, J. H., Jang, J. W., Kim, H. J., Choi, S. H., & Kwon, S. W. (2018). Decellularized sciatic nerve matrix as a biodegradable conduit for peripheral nerve regeneration. Neural regeneration research, 13(10), 1796-1803. https://doi.org/10.4103/1673-5374.237126
Choi, Jongbae, et al. "Decellularized sciatic nerve matrix as a biodegradable conduit for peripheral nerve regeneration." Neural regeneration research vol. 13,10 (2018): 1796-1803. doi: https://doi.org/10.4103/1673-5374.237126
Choi J, Kim JH, Jang JW, Kim HJ, Choi SH, Kwon SW. Decellularized sciatic nerve matrix as a biodegradable conduit for peripheral nerve regeneration. Neural Regen Res. 2018 Oct;13(10):1796-1803. doi: 10.4103/1673-5374.237126. PMID: 30136695; PMCID: PMC6128056.
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Neural Regen Res. 2018 Oct;13(10):1796-1803. doi: 10.4103/1673-5374.237126.

Decellularized sciatic nerve matrix as a biodegradable conduit for peripheral nerve regeneration.

Neural regeneration research

Jongbae Choi, Jun Ho Kim, Ji Wook Jang, Hyun Jung Kim, Sung Hoon Choi, Sung Won Kwon

Affiliations

  1. R&D Center, Genewel Co., Ltd., Seongnam-si, Gyeonggi-do, Korea.
  2. Department of Surgery, CHA Bundang Medical Center, CHA University, Seongnam-si, Gyeonggi-do, Korea.

PMID: 30136695 PMCID: PMC6128056 DOI: 10.4103/1673-5374.237126

Abstract

The use of autologous nerve grafts remains the gold standard for treating nerve defects, but current nerve repair techniques are limited by donor tissue availability and morbidity associated with tissue loss. Recently, the use of conduits in nerve injury repair, made possible by tissue engineering, has shown therapeutic potential. We manufactured a biodegradable, collagen-based nerve conduit containing decellularized sciatic nerve matrix and compared this with a silicone conduit for peripheral nerve regeneration using a rat model. The collagen-based conduit contains nerve growth factor, brain-derived neurotrophic factor, and laminin, as demonstrated by enzyme-linked immunosorbent assay. Scanning electron microscopy images showed that the collagen-based conduit had an outer wall to prevent scar tissue infiltration and a porous inner structure to allow axonal growth. Rats that were implanted with the collagen-based conduit to bridge a sciatic nerve defect experienced significantly improved motor and sensory nerve functions and greatly enhanced nerve regeneration compared with rats in the sham control group and the silicone conduit group. Our results suggest that the biodegradable collagen-based nerve conduit is more effective for peripheral nerve regeneration than the silicone conduit.

Keywords: biodegradable; collagen; decellularized; growth factor; nerve conduit; nerve regeneration; peripheral nerve injury; rat model; regeneration; silicone conduit

Conflict of interest statement

We have received research grants from the Small and Medium Business Administration and collaborated with Genewel. We have used Genewel's laboratory and animal laboratories. There are no conflicts of i

References

  1. J Comp Neurol. 1987 Oct 8;264(2):284-90 - PubMed
  2. Ann Plast Surg. 2008 Jan;60(1):110-6 - PubMed
  3. Exp Neurol. 1982 Sep;77(3):634-43 - PubMed
  4. J Mater Sci Mater Med. 2012 Aug;23(8):1835-47 - PubMed
  5. Injury. 2012 May;43(5):553-72 - PubMed
  6. J Neurosci Methods. 2000 Mar 15;96(2):89-96 - PubMed
  7. Tissue Eng Part A. 2017 Feb;23(3-4):124-134 - PubMed
  8. Exp Neurol. 1998 Jan;149(1):243-52 - PubMed
  9. Exp Neurol. 2003 Nov;184(1):295-303 - PubMed
  10. J Cell Biol. 2003 Nov 24;163(4):889-99 - PubMed
  11. J Hand Surg Am. 2011 Sep;36(9):1441-6 - PubMed
  12. Exp Neurol. 1990 Mar;107(3):222-9 - PubMed
  13. Neurol Res. 2004 Mar;26(2):151-60 - PubMed
  14. Biomed Res Int. 2016;2016:3856262 - PubMed
  15. Microsurgery. 1990;11(2):191-2 - PubMed
  16. Microsurgery. 2009;29(2):107-14 - PubMed
  17. Arch Otolaryngol Head Neck Surg. 1996 Apr;122(4):407-13 - PubMed
  18. Plast Reconstr Surg. 1989 Jan;83(1):129-38 - PubMed
  19. Microsurgery. 1993;14(5):323-7 - PubMed
  20. J Neurosci Methods. 2000 Oct 30;102(2):109-16 - PubMed
  21. J Am Acad Orthop Surg. 2000 Jul-Aug;8(4):243-52 - PubMed
  22. Microsurgery. 1989;10(3):220-5 - PubMed
  23. Exp Neurol. 1987 Feb;95(2):378-90 - PubMed
  24. Macromol Biosci. 2006 Jan 5;6(1):13-26 - PubMed
  25. Tissue Eng Part C Methods. 2010 Dec;16(6):1585-96 - PubMed
  26. Br J Plast Surg. 1998 Dec;51(8):637-9 - PubMed
  27. Pain. 1979 Oct;7(2):103-11 - PubMed
  28. Folia Morphol (Warsz). 2009 Feb;68(1):1-7 - PubMed
  29. Tissue Eng Part A. 2009 Nov;15(11):3297-308 - PubMed
  30. Microsurgery. 2001;21(8):383-8 - PubMed
  31. Sci Rep. 2018 Jan 12;8(1):604 - PubMed
  32. Restor Neurol Neurosci. 1999;14(1):65-79 - PubMed
  33. Muscle Nerve. 1990 Sep;13(9):785-800 - PubMed
  34. Neurosurgery. 2008 Jul;63(1):144-53; discussion 153-5 - PubMed
  35. Brain. 2005 Aug;128(Pt 8):1897-910 - PubMed

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