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Marsakatla P, Suneetha S, Lee J, et al. Insights from the sequence similarity of Zika virus proteins with the Human nerve proteins. Bioinformation. 2018;14(5):194-200doi: 10.6026/97320630014194.
Marsakatla, P., Suneetha, S., Lee, J., Swaminathan, P. D., Vasudevan, L., Supriya, R., & Suneetha, L. M. (2018). Insights from the sequence similarity of Zika virus proteins with the Human nerve proteins. Bioinformation, 14(5), 194-200. https://doi.org/10.6026/97320630014194
Marsakatla, Prasanna, et al. "Insights from the sequence similarity of Zika virus proteins with the Human nerve proteins." Bioinformation vol. 14,5 (2018): 194-200. doi: https://doi.org/10.6026/97320630014194
Marsakatla P, Suneetha S, Lee J, Swaminathan PD, Vasudevan L, Supriya R, Suneetha LM. Insights from the sequence similarity of Zika virus proteins with the Human nerve proteins. Bioinformation. 2018 May 31;14(5):194-200. doi: 10.6026/97320630014194. eCollection 2018. PMID: 30108415; PMCID: PMC6077820.
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Bioinformation. 2018 May 31;14(5):194-200. doi: 10.6026/97320630014194. eCollection 2018.

Insights from the sequence similarity of Zika virus proteins with the Human nerve proteins.

Bioinformation

Prasanna Marsakatla, Sujai Suneetha, Joshua Lee, Paari Dominic Swaminathan, Logeshwaran Vasudevan, Rachael Supriya, Lavanya Moses Suneetha

Affiliations

  1. CODEWEL Nireekshana ACET, Narayanaguda, Hyderabad -500029, Telangana, India.
  2. York University, Department of Science, 4700 Keele St, Toronto, ON M3J 1P3, Canada.
  3. LSU Health Sciences Center, Center for Cardiovascular Diseases and Sciences Shreveport, LA, USA.
  4. Presidency College, Department of Zoology, Chennai-05, India.

PMID: 30108415 PMCID: PMC6077820 DOI: 10.6026/97320630014194

Abstract

Massive peptide sharing between the Zika virus polyprotein and host tissue proteins could elicit significant host-pathogen interactions and cross-reactions leading to autoimmune diseases. This study found similarities in the Zika V proteins and human nerve tissue proteins. 63 human nerve proteins were screened for similarities with the Zika V of which Neuromodulin, Nestin, Galanin, Bombesin, Calcium-binding protein were found to have similarities to the Zika V poly protein C at different sequence regions. These sequence similarities could be significant in regulating pathogenic interactions/autoimmunity, as Polyprotein C is known to be a virulent factor.

Keywords: BLAST; Bioinformatics; Bombesin; Calcium-binding protein; Galanin; Nerve tissue proteins; Nestin; Neuromodulin; Neuropathogenesis; Zika V

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