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Genes Cancer. 2018 Mar;9(3):114-129. doi: 10.18632/genesandcancer.173.

The expression of genes contributing to pancreatic adenocarcinoma progression is influenced by the respective environment.

Genes & cancer

Micah N Sagini, Michael Zepp, Frank Bergmann, Matthias Bozza, Richard Harbottle, Martin R Berger

Affiliations

  1. Toxicology and Chemotherapy Unit, German Cancer Research Center (DKFZ), Heidelberg, Germany.
  2. University Clinic of Heidelberg, Institute of Pathology, Heidelberg, Germany.
  3. DNA Vectors, German Cancer Research Center (DKFZ), Heidelberg, Germany.

PMID: 30108682 PMCID: PMC6086001 DOI: 10.18632/genesandcancer.173

Abstract

Pancreatic adenocarcinoma is a highly aggressive malignancy with dismal prognosis and limited curative options. We investigated the influence of organ environments on gene expression in RNU rats by orthotopic and intraportal infusion of Suit2-007

Keywords: PDAC; TGM2; gene expression profiles; tumor micro-environment; tumor model

Conflict of interest statement

CONFLICT OF INTEREST The authors declare to have no conflict of interest.

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