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Roscales S, Bechmann N, Weiss DH, et al. Novel valdecoxib derivatives by ruthenium(ii)-promoted 1,3-dipolar cycloaddition of nitrile oxides with alkynes - synthesis and COX-2 inhibition activity. Medchemcomm. 2018;9(3):534-544doi: 10.1039/c7md00575j.
Roscales, S., Bechmann, N., Weiss, D. H., Köckerling, M., Pietzsch, J., & Kniess, T. (2018). Novel valdecoxib derivatives by ruthenium(ii)-promoted 1,3-dipolar cycloaddition of nitrile oxides with alkynes - synthesis and COX-2 inhibition activity. MedChemComm, 9(3), 534-544. https://doi.org/10.1039/c7md00575j
Roscales, Silvia, et al. "Novel valdecoxib derivatives by ruthenium(ii)-promoted 1,3-dipolar cycloaddition of nitrile oxides with alkynes - synthesis and COX-2 inhibition activity." MedChemComm vol. 9,3 (2018): 534-544. doi: https://doi.org/10.1039/c7md00575j
Roscales S, Bechmann N, Weiss DH, Köckerling M, Pietzsch J, Kniess T. Novel valdecoxib derivatives by ruthenium(ii)-promoted 1,3-dipolar cycloaddition of nitrile oxides with alkynes - synthesis and COX-2 inhibition activity. Medchemcomm. 2018 Feb 13;9(3):534-544. doi: 10.1039/c7md00575j. eCollection 2018 Mar 01. PMID: 30108944; PMCID: PMC6072335.
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Medchemcomm. 2018 Feb 13;9(3):534-544. doi: 10.1039/c7md00575j. eCollection 2018 Mar 01.

Novel valdecoxib derivatives by ruthenium(ii)-promoted 1,3-dipolar cycloaddition of nitrile oxides with alkynes - synthesis and COX-2 inhibition activity.

MedChemComm

Silvia Roscales, Nicole Bechmann, Daniel Holger Weiss, Martin Köckerling, Jens Pietzsch, Torsten Kniess

Affiliations

  1. Department of Radiopharmaceutical and Chemical Biology , Helmholtz-Zentrum Dresden-Rossendorf , Institute of Radiopharmaceutical Cancer Research , Bautzner Landstraße 400 , 01328 Dresden , Germany . Email: [email protected].
  2. Department of Inorganic Solid State Chemistry , Institute of Chemistry , University of Rostock , Albert Einstein Straße 3a , 18059 Rostock , Germany.
  3. Department of Chemistry and Food Chemistry , Technische Universität Dresden , Bergstraße 66 , 01062 Dresden , Germany.

PMID: 30108944 PMCID: PMC6072335 DOI: 10.1039/c7md00575j

Abstract

Novel valdecoxib-based cyclooxygenase-2 inhibitors were synthesized in one step

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