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Gebremeskel L, Bhoumik D, Sibhat GG, et al. . Evid Based Complement Alternat Med. 2018;2018:5037912doi: 10.1155/2018/5037912.
Gebremeskel, L., Bhoumik, D., Sibhat, G. G., & Tuem, K. B. (2018). . Evidence-based complementary and alternative medicine : eCAM, 20185037912. https://doi.org/10.1155/2018/5037912
Gebremeskel, Leake, et al. "." Evidence-based complementary and alternative medicine : eCAM vol. 2018 (2018): 5037912. doi: https://doi.org/10.1155/2018/5037912
Gebremeskel L, Bhoumik D, Sibhat GG, Tuem KB. . Evid Based Complement Alternat Med. 2018 Jul 02;2018:5037912. doi: 10.1155/2018/5037912. eCollection 2018. PMID: 30057643; PMCID: PMC6051243.
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Evid Based Complement Alternat Med. 2018 Jul 02;2018:5037912. doi: 10.1155/2018/5037912. eCollection 2018.

[No title available]

Evidence-based complementary and alternative medicine : eCAM

Leake Gebremeskel, Dayananda Bhoumik, Gereziher Geremedhin Sibhat, Kald Beshir Tuem

Affiliations

  1. Department of Pharmacy, College of Health Sciences, Aksum University, Aksum, Ethiopia.
  2. Department of Pharmacology and Toxicology, School of Pharmacy, College of Health Sciences, Mekelle University, Mekelle, Ethiopia.
  3. Department of Pharmacognosy, School of Pharmacy, College of Health Sciences, Mekelle University, Mekelle, Ethiopia.

PMID: 30057643 PMCID: PMC6051243 DOI: 10.1155/2018/5037912

Abstract

PURPOSE: The aim of this study was to evaluate

METHODS: The wound healing activity of the leaf latex of the plant was studied topically by incorporating the latex in simple ointment base in a concentration of 5% (w/w) and 10% (w/w) using excision and incision models. In these models, wound contraction, period of epithelialization, and breaking strength of the wounded skin were determined. Carrageenan induced inflammation of paw model was also used to assess the anti-inflammatory activity of the leaf latex at doses of 200 mg/kg, 400mg/kg, and 600 mg/kg. The level of inflammation suppressions were measured at 1, 2, 3, and 4 hrs after carrageenan injection, and then the percentages of inflammation inhibition were computed as compared with the negative control.

RESULT: In both wound models, mice treated with 5% (w/w) and 10% (w/w) latex ointment showed a significant (p<0.05) increment in the rate of wound contraction, reduction in epithelialization time, and higher skin breaking strength. Besides, the latex also exhibited a dose-dependent significant (p<0.05) reductions of inflammation as compared to negative control groups.

CONCLUSION: The overall results of this study demonstrate that the leaf latex of

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