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Samburova V, Bhattarai C, Strickland M, et al. Aldehydes in Exhaled Breath during E-Cigarette Vaping: Pilot Study Results. Toxics. 2018;6(3)doi: 10.3390/toxics6030046.
Samburova, V., Bhattarai, C., Strickland, M., Darrow, L., Angermann, J., Son, Y., & Khlystov, A. (2018). Aldehydes in Exhaled Breath during E-Cigarette Vaping: Pilot Study Results. Toxics, 6(3), . https://doi.org/10.3390/toxics6030046
Samburova, Vera, et al. "Aldehydes in Exhaled Breath during E-Cigarette Vaping: Pilot Study Results." Toxics vol. 6,3 (2018). doi: https://doi.org/10.3390/toxics6030046
Samburova V, Bhattarai C, Strickland M, Darrow L, Angermann J, Son Y, Khlystov A. Aldehydes in Exhaled Breath during E-Cigarette Vaping: Pilot Study Results. Toxics. 2018 Aug 07;6(3). doi: 10.3390/toxics6030046. PMID: 30087275; PMCID: PMC6161081.
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Toxics. 2018 Aug 07;6(3). doi: 10.3390/toxics6030046.

Aldehydes in Exhaled Breath during E-Cigarette Vaping: Pilot Study Results.

Toxics

Vera Samburova, Chiranjivi Bhattarai, Matthew Strickland, Lyndsey Darrow, Jeff Angermann, Yeongkwon Son, Andrey Khlystov

Affiliations

  1. Organic Analytical Laboratory, Desert Research Institute (DRI), Reno, NV 89512, USA. [email protected].
  2. Organic Analytical Laboratory, Desert Research Institute (DRI), Reno, NV 89512, USA. [email protected].
  3. School of Community Health Sciences, University of Nevada, Reno, NV 89557, USA. [email protected].
  4. School of Community Health Sciences, University of Nevada, Reno, NV 89557, USA. [email protected].
  5. School of Community Health Sciences, University of Nevada, Reno, NV 89557, USA. [email protected].
  6. Organic Analytical Laboratory, Desert Research Institute (DRI), Reno, NV 89512, USA. [email protected].
  7. Organic Analytical Laboratory, Desert Research Institute (DRI), Reno, NV 89512, USA. [email protected].

PMID: 30087275 PMCID: PMC6161081 DOI: 10.3390/toxics6030046

Abstract

Several studies have shown the presence of aldehydes (i.e., formaldehyde, acrolein) in mainstream emissions of some e-cigarettes. For this reason, concerns have been raised regarding potential toxicity. The purpose of this research was to measure levels of carbonyls in exhaled breath of e-cigarette users during "vaping" sessions and estimate the respiratory tract (RT) uptake of specific aldehydes, including formaldehyde and acetaldehyde. We measured concentrations of 12 carbonyls in e-cigarette aerosols produced directly by e-cigarettes and in the exhaled breath of 12 participants (19 sessions). Carbonyls were sampled on 2,4-dinitrophenylhydrazine (DNPH) cartridges and analyzed with high performance liquid chromatography (HPLC) coupled with a UV/Vis photodiode detector. We found that in most cases, levels of aldehydes and methyl ethyl ketone (MEK) were significantly higher (2⁻125 times) in exhaled e-cigarette breaths than in pre-exposed breath. Exposure levels for the most abundant individual carbonyls in e-cigarette emissions-formaldehyde, acetaldehyde, acrolein-were between the limit of quantification (LOQ) and 24.4 μg·puff

Keywords: aldehydes; breath analysis; e-cigarette emissions; exposure; respiratory tract retention

References

  1. MMWR Morb Mortal Wkly Rep. 2016 Apr 15;65(14):361-7 - PubMed
  2. Tob Control. 2016 Apr;25(e1):e10-5 - PubMed
  3. Tob Control. 2014 Mar;23(2):133-9 - PubMed
  4. Mol Nutr Food Res. 2011 Sep;55(9):1342-60 - PubMed
  5. Arch Environ Health. 1972 Aug;25(2):119-24 - PubMed
  6. Mol Nutr Food Res. 2011 Sep;55(9):1291-300 - PubMed
  7. Toxicol Sci. 2001 Nov;64(1):122-34 - PubMed
  8. Regul Toxicol Pharmacol. 2014 Dec;70(3):704-10 - PubMed
  9. Int J Hyg Environ Health. 2014 Jul;217(6):628-37 - PubMed
  10. Toxicol Appl Pharmacol. 2005 Aug 15;206(3):309-20 - PubMed
  11. Int J Environ Res Public Health. 2014 Oct 28;11(11):11192-200 - PubMed
  12. PLoS One. 2015 Feb 09;10(2):e0117222 - PubMed
  13. Int J Environ Res Public Health. 2014 Oct 27;11(11):11177-91 - PubMed
  14. Arch Environ Health. 1968 Nov;17(5):746-8 - PubMed
  15. Nicotine Tob Res. 2010 Sep;12(9):905-12 - PubMed
  16. Environ Sci Technol. 2016 Dec 6;50(23):13080-13085 - PubMed
  17. Nicotine Tob Res. 2015 Feb;17(2):228-35 - PubMed
  18. Nicotine Tob Res. 2015 Feb;17(2):150-7 - PubMed
  19. Environ Sci Technol. 2016 Sep 6;50(17):9644-51 - PubMed
  20. Thorax. 2016 Apr;71(4):376-7 - PubMed
  21. Sci Rep. 2018 May 15;8(1):7559 - PubMed
  22. Regul Toxicol Pharmacol. 2016 Mar;75:58-65 - PubMed
  23. N Engl J Med. 2015 Jan 22;372(4):392-4 - PubMed
  24. Environ Health Perspect. 2016 Jun;124(6):733-9 - PubMed
  25. Nicotine Tob Res. 2014 Oct;16(10):1319-26 - PubMed
  26. Tob Control. 2014 May;23 Suppl 2:ii23-9 - PubMed
  27. Addict Behav. 2012 Aug;37(8):970-3 - PubMed
  28. Addiction. 2015 Aug;110(8):1352-6 - PubMed
  29. Anal Sci. 2016;32(5):549-55 - PubMed
  30. Am J Prev Med. 2017 Jul;53(1):96-101 - PubMed

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