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Guarnieri M, Brayton C, Tyler BM. A Long-Term Study of a Lipid-Buprenorphine Implant in Rats. J Vet Med. 2018;2018:2616152doi: 10.1155/2018/2616152.
Guarnieri, M., Brayton, C., & Tyler, B. M. (2018). A Long-Term Study of a Lipid-Buprenorphine Implant in Rats. Journal of veterinary medicine, 20182616152. https://doi.org/10.1155/2018/2616152
Guarnieri, Michael, et al. "A Long-Term Study of a Lipid-Buprenorphine Implant in Rats." Journal of veterinary medicine vol. 2018 (2018): 2616152. doi: https://doi.org/10.1155/2018/2616152
Guarnieri M, Brayton C, Tyler BM. A Long-Term Study of a Lipid-Buprenorphine Implant in Rats. J Vet Med. 2018 Jul 09;2018:2616152. doi: 10.1155/2018/2616152. eCollection 2018. PMID: 30112418; PMCID: PMC6077592.
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J Vet Med. 2018 Jul 09;2018:2616152. doi: 10.1155/2018/2616152. eCollection 2018.

A Long-Term Study of a Lipid-Buprenorphine Implant in Rats.

Journal of veterinary medicine

Michael Guarnieri, Cory Brayton, Betty M Tyler

Affiliations

  1. Johns Hopkins School of Medicine, Department of Neurological Surgery, Baltimore, MD, USA.
  2. Johns Hopkins School of Medicine, Department of Molecular and Comparative Pathobiology, Baltimore, MD, USA.

PMID: 30112418 PMCID: PMC6077592 DOI: 10.1155/2018/2616152

Abstract

Animal models to study opiates are of growing interest. We have examined the short-term safety of buprenorphine implants in Fischer F344/NTac rats treated with excess doses of a cholesterol-triglyceride suspension of buprenorphine. A single injection of 0.65 mg/kg afforded clinically significant blood levels of analgesia for 3 days. Chemistry, hematology, coagulation, and urinalysis values with 2- to 10-fold excess doses of the drug-lipid suspension were within normal limits. Histopathology findings were unremarkable. The skin and underlying tissue surrounding the drug injection were unremarkable. Here we report the results of a long-term follow-up study of female rats injected with 0.65 and 1.3 mg/kg. The 14-month evaluation showed no abnormal findings that could be attributed to the drug or lipid suspension. These results confirm the safety of cholesterol-triglyceride carrier systems for subcutaneous drug delivery in laboratory animals and suggest that this model may be used to study long-term effects of opiate therapy.

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