Display options
Cite
Vinagre CG, Freitas FR, de Mesquita CH, et al. Removal of Chylomicron Remnants from the Bloodstream is Delayed in Aged Subjects. Aging Dis. 2018;9(4):748-754doi: 10.14336/AD.2017.1003.
Vinagre, C. G., Freitas, F. R., de Mesquita, C. H., Vinagre, J. C., Mariani, A. C., Kalil-Filho, R., & Maranhão, R. C. (2018). Removal of Chylomicron Remnants from the Bloodstream is Delayed in Aged Subjects. Aging and disease, 9(4), 748-754. https://doi.org/10.14336/AD.2017.1003
Vinagre, Carmen G, et al. "Removal of Chylomicron Remnants from the Bloodstream is Delayed in Aged Subjects." Aging and disease vol. 9,4 (2018): 748-754. doi: https://doi.org/10.14336/AD.2017.1003
Vinagre CG, Freitas FR, de Mesquita CH, Vinagre JC, Mariani AC, Kalil-Filho R, Maranhão RC. Removal of Chylomicron Remnants from the Bloodstream is Delayed in Aged Subjects. Aging Dis. 2018 Aug 01;9(4):748-754. doi: 10.14336/AD.2017.1003. eCollection 2018 Aug. PMID: 30090662; PMCID: PMC6065288.
Copy Download .nbib Format: NLM
Share it on

Aging Dis. 2018 Aug 01;9(4):748-754. doi: 10.14336/AD.2017.1003. eCollection 2018 Aug.

Removal of Chylomicron Remnants from the Bloodstream is Delayed in Aged Subjects.

Aging and disease

Carmen G Vinagre, Fatima R Freitas, Carlos H de Mesquita, Juliana C Vinagre, Ana Carolina Mariani, Roberto Kalil-Filho, Raul C Maranhão

Affiliations

  1. 1Heart Institute (InCor) of Medical School Hospital, University of São Paulo, São Paulo, Brazil.
  2. 2University of Santo Amaro, São Paulo, Brazil.
  3. 3Institute of Nuclear Research, University of São Paulo, São Paulo, Brazil.
  4. 4Faculty of Pharmaceutical Sciences, University of São Paulo, São Paulo, Brazil.

PMID: 30090662 PMCID: PMC6065288 DOI: 10.14336/AD.2017.1003

Abstract

Dietary fats absorbed in the intestine are transported in the circulation as chylomicrons and remnants that have atherogenic potential. Although postprandial lipidemia is increased in older subjects, the specific chylomicron metabolism has not been explored in older subjects nor compared to young subjects, which is the focus of this study. After a 12 h fast, artificially-made emulsions similar to lymph chylomicrons and doubly labeled with radioactive cholesteryl esters and triglycerides were intravenously injected in 23 older (66±4 years) and 20 young (24±3 years) subjects. Sequential blood samples were collected to determine fractional clearance rates (FCR, in min

Keywords: Aging and atherosclerosis; cholesterol and aging; chylomicron remnants; emulsions; triglyceride

Conflict of interest statement

Conflicts of Interest The authors declare that they have no conflicts of interest.

References

  1. Clin Chim Acta. 2011 Jul 15;412(15-16):1306-18 - PubMed
  2. Methods Enzymol. 1986;129:716-38 - PubMed
  3. Transplantation. 2000 Feb 27;69(4):532-7 - PubMed
  4. Ann ICRP. 2009 Oct;39(5):7-68 - PubMed
  5. J Clin Invest. 1990 Mar;85(3):883-92 - PubMed
  6. J Clin Invest. 1970 Mar;49(3):465-71 - PubMed
  7. Aging (Milano). 1996 Dec;8(6):421-8 - PubMed
  8. J Lipid Res. 2004 Sep;45(9):1594-607 - PubMed
  9. Lipids. 2001 Feb;36(2):115-20 - PubMed
  10. Atherosclerosis. 2010 Jul;211(1):1-8 - PubMed
  11. Clin Sci (Lond). 2003 Oct;105(4):457-66 - PubMed
  12. Biochim Biophys Acta. 2012 May;1821(5):721-6 - PubMed
  13. Am J Physiol Endocrinol Metab. 2011 Aug;301(2):E356-61 - PubMed
  14. J Clin Invest. 1993 Mar;91(3):748-58 - PubMed
  15. Biochim Biophys Acta. 1987 Feb 14;917(2):344-6 - PubMed
  16. J Lipid Res. 1993 Dec;34(12):2033-40 - PubMed
  17. J Lipid Res. 1987 May;28(5):473-82 - PubMed
  18. Metabolism. 1999 Mar;48(3):301-7 - PubMed
  19. J Lipid Res. 1988 Apr;29(4):469-79 - PubMed
  20. Atherosclerosis. 2002 Apr;161(2):447-53 - PubMed
  21. Arch Gerontol Geriatr. 1983 Jul;2(1-2):41-8 - PubMed
  22. J Gerontol A Biol Sci Med Sci. 1998 Mar;53(2):B133-40 - PubMed
  23. J Gerontol A Biol Sci Med Sci. 2000 Nov;55(11):B515-21 - PubMed
  24. Atherosclerosis. 2014 Mar;233(1):319-25 - PubMed
  25. Atherosclerosis. 1996 Sep 27;126(1):15-25 - PubMed
  26. Mech Ageing Dev. 2002 Apr 30;123(8):1183-9 - PubMed
  27. Eur J Nutr. 2014 Apr;53(3):981-7 - PubMed
  28. J Atheroscler Thromb. 2003;10(3):132-9 - PubMed
  29. J Lipid Res. 1996 Jan;37(1):197-209 - PubMed
  30. Br J Nutr. 2016 Mar 14;115(5):791-9 - PubMed

Publication Types