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Boehringer R, Kieffer B, Torbeev V. Total chemical synthesis and biophysical properties of a designed soluble 24 kDa amyloid analogue. Chem Sci. 2018;9(25):5594-5599doi: 10.1039/c8sc01790e.
Boehringer, R., Kieffer, B., & Torbeev, V. (2018). Total chemical synthesis and biophysical properties of a designed soluble 24 kDa amyloid analogue. Chemical science, 9(25), 5594-5599. https://doi.org/10.1039/c8sc01790e
Boehringer, Régis, et al. "Total chemical synthesis and biophysical properties of a designed soluble 24 kDa amyloid analogue." Chemical science vol. 9,25 (2018): 5594-5599. doi: https://doi.org/10.1039/c8sc01790e
Boehringer R, Kieffer B, Torbeev V. Total chemical synthesis and biophysical properties of a designed soluble 24 kDa amyloid analogue. Chem Sci. 2018 May 25;9(25):5594-5599. doi: 10.1039/c8sc01790e. eCollection 2018 Jul 07. PMID: 30061991; PMCID: PMC6049524.
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Chem Sci. 2018 May 25;9(25):5594-5599. doi: 10.1039/c8sc01790e. eCollection 2018 Jul 07.

Total chemical synthesis and biophysical properties of a designed soluble 24 kDa amyloid analogue.

Chemical science

Régis Boehringer, Bruno Kieffer, Vladimir Torbeev

Affiliations

  1. Institut de Science et d'Ingénierie Supramoléculaires (ISIS) , International Center for Frontier Research in Chemistry (icFRC) , University of Strasbourg , CNRS (UMR 7006) , Strasbourg , France . Email: [email protected].
  2. Department of Integrated Structural Biology , Institut de Génétique et de Biologie Moléculaire et Cellulaire (IGBMC) , INSERM (U964) , University of Strasbourg , CNRS (UMR 7104) , Illkirch , France.

PMID: 30061991 PMCID: PMC6049524 DOI: 10.1039/c8sc01790e

Abstract

Discovering molecular probes that specifically recognize distinct amyloid structures is highly important for physiological studies of protein-misfolding diseases as well as for the development of diagnostic reagents and inhibitors of amyloid self-assembly. Here, we demonstrate an approach that allows for identification of

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