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Hermans D, Webby RJ, Wong SS. Atypical antibody responses to influenza. J Thorac Dis. 2018;10:S2238-S2247doi: 10.21037/jtd.2017.12.122.
Hermans, D., Webby, R. J., & Wong, S. S. (2018). Atypical antibody responses to influenza. Journal of thoracic disease, 10S2238-S2247. https://doi.org/10.21037/jtd.2017.12.122
Hermans, Dalton, et al. "Atypical antibody responses to influenza." Journal of thoracic disease vol. 10 (2018): S2238-S2247. doi: https://doi.org/10.21037/jtd.2017.12.122
Hermans D, Webby RJ, Wong SS. Atypical antibody responses to influenza. J Thorac Dis. 2018 Jul;10:S2238-S2247. doi: 10.21037/jtd.2017.12.122. PMID: 30116603; PMCID: PMC6072921.
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J Thorac Dis. 2018 Jul;10:S2238-S2247. doi: 10.21037/jtd.2017.12.122.

Atypical antibody responses to influenza.

Journal of thoracic disease

Dalton Hermans, Richard J Webby, Sook-San Wong

Affiliations

  1. Department of Pediatrics, University of Wisconsin-Madison, Madison, WI 53715, USA.
  2. Department of Infectious Diseases, St. Jude Children's Research Hospital, Memphis, TN 38105, USA.

PMID: 30116603 PMCID: PMC6072921 DOI: 10.21037/jtd.2017.12.122

Abstract

Influenza viruses undergo rapid antigenic evolution and reassortment, resulting in annual epidemics and the occasional pandemics. Exposure to influenza virus hemagglutinin (HA) and neuraminidase (NA) antigen, either through vaccination or infection, induces an antibody response able to recognize only the homologous antigenic subtype. However, atypical antibody responses recognizing non-homologous influenza subtypes have been reported during infection and vaccination. Here, we review the incidence of these phenomena in published literature and discuss the potential mechanisms underlying them.

Keywords: Influenza; antibody; heterosubtypic; neutralizing

Conflict of interest statement

Conflicts of Interest: The authors have no conflicts of interest to declare.

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