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Nikitenko NA, Gureeva ES, Ozerov AA, et al. 1-(4-Phenoxybenzyl) 5-Aminouracil Derivatives and Their Analogues - Novel Inhibitors of Human Adenovirus Replication. Acta Naturae. 2018;10(2):58-64
Nikitenko, N. A., Gureeva, E. S., Ozerov, A. A., Tukhvatulin, A. I., Izhaeva, F. M., Prassolov, V. S., Deryabin, P. G., Novikov, M. S., & Logunov, D. Y. (2018). 1-(4-Phenoxybenzyl) 5-Aminouracil Derivatives and Their Analogues - Novel Inhibitors of Human Adenovirus Replication. Acta naturae, 10(2), 58-64.
Nikitenko, N A, et al. "1-(4-Phenoxybenzyl) 5-Aminouracil Derivatives and Their Analogues - Novel Inhibitors of Human Adenovirus Replication." Acta naturae vol. 10,2 (2018): 58-64.
Nikitenko NA, Gureeva ES, Ozerov AA, Tukhvatulin AI, Izhaeva FM, Prassolov VS, Deryabin PG, Novikov MS, Logunov DY. 1-(4-Phenoxybenzyl) 5-Aminouracil Derivatives and Their Analogues - Novel Inhibitors of Human Adenovirus Replication. Acta Naturae. 2018 Apr-Jun;10(2):58-64. PMID: 30116616; PMCID: PMC6087815.
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Acta Naturae. 2018 Apr-Jun;10(2):58-64.

1-(4-Phenoxybenzyl) 5-Aminouracil Derivatives and Their Analogues - Novel Inhibitors of Human Adenovirus Replication.

Acta naturae

N A Nikitenko, E S Gureeva, A A Ozerov, A I Tukhvatulin, F M Izhaeva, V S Prassolov, P G Deryabin, M S Novikov, D Y Logunov

Affiliations

  1. N.F. Gamaleya Federal National Research Center for Epidemiology and Microbiology, Gamaleya Str. 18, Moscow, 123098, Russia.
  2. Volgograd State Medical University, Pavshih Bortsov Sq. 1,Volgograd, 400131, Russia.
  3. Engelhardt Institute of Molecular Biology, Russian Academy of Sciences, Vavilova Str. 32, Moscow, 119991, Russia.

PMID: 30116616 PMCID: PMC6087815

Abstract

Adenovirus infections are characterized by widespread distribution. The lack of causal therapy, which is effective in treating this group of diseases, explains the need for new therapeutic drugs. Notably, anti-adenoviral activity of [4-(phenoxy)benzyl]-5-(phenylamino)-6-azauracil, 1-[4-(phenoxy)benzyl]-5-(morpholino) uracil, 1-[4-(4-chlorophenoxy)benzyl]-5-(morpholino) uracil, and 1-[4-(4-fluorophenoxy)-benzyl]-5-(morpholino) uracil was observed.

Keywords: 5-aminouracil derivatives; Human adenovirus; adenovirus replication; inhibitors of adenovirus replication

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