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Hu L, Han F, Chen L, et al. High nutrient intake during the early postnatal period accelerates skeletal muscle fiber growth and maturity in intrauterine growth-restricted pigs. Genes Nutr. 2018;13:23doi: 10.1186/s12263-018-0612-8.
Hu, L., Han, F., Chen, L., Peng, X., Chen, D., Wu, Che, L., & Zhang, K. (2018). High nutrient intake during the early postnatal period accelerates skeletal muscle fiber growth and maturity in intrauterine growth-restricted pigs. Genes & nutrition, 1323. https://doi.org/10.1186/s12263-018-0612-8
Hu, Liang, et al. "High nutrient intake during the early postnatal period accelerates skeletal muscle fiber growth and maturity in intrauterine growth-restricted pigs." Genes & nutrition vol. 13 (2018): 23. doi: https://doi.org/10.1186/s12263-018-0612-8
Hu L, Han F, Chen L, Peng X, Chen D, Wu, Che L, Zhang K. High nutrient intake during the early postnatal period accelerates skeletal muscle fiber growth and maturity in intrauterine growth-restricted pigs. Genes Nutr. 2018 Jul 27;13:23. doi: 10.1186/s12263-018-0612-8. eCollection 2018. PMID: 30065792; PMCID: PMC6062929.
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Genes Nutr. 2018 Jul 27;13:23. doi: 10.1186/s12263-018-0612-8. eCollection 2018.

High nutrient intake during the early postnatal period accelerates skeletal muscle fiber growth and maturity in intrauterine growth-restricted pigs.

Genes & nutrition

Liang Hu, Fei Han, Lin Chen, Xie Peng, Daiwen Chen, De Wu, Lianqiang Che, Keying Zhang

Affiliations

  1. Institute of Animal Nutrition, Key Laboratory of Animal Disease-Resistance Nutrition, Sichuan Agricultural University, Ministry of Education, No.211 Huimin Road, Wenjiang District, Chengdu, 611130 Sichuan People's Republic of China.

PMID: 30065792 PMCID: PMC6062929 DOI: 10.1186/s12263-018-0612-8

Abstract

BACKGROUND: Intrauterine growth-restricted (IUGR) neonates impair postnatal skeletal muscle growth. The aim of this study was to investigate whether high nutrient intake (HNI) during the suckling period could improve muscle growth and metabolic status of IUGR pigs.

METHODS: Twelve pairs of IUGR and normal birth weight (NBW) pigs (7 days old) were randomly assigned to adequate nutrient intake and HNI formula milk groups. Psoas major (PM) muscle sample was obtained after 21 days of rearing.

RESULTS: IUGR decreased cross-sectional areas (CSA) and myofiber numbers, activity of lactate dehydrogenase (LDH), and mRNA expression of insulin-like growth factor 1 (IGF-1), IGF-1 receptor (IGF-1R), mammalian target of rapamycin (mTOR), ribosomal protein s6 (RPS6), eukaryotic translation initiation factor 4E (eIF4E), protein expression of phosphorylated mTOR (P-mTOR), and phosphorylated protein kinase B (P-Akt) in the PM muscle of pigs. Irrespective of birth weight, HNI increased muscle weight and CSA, the concentration of RNA, and ratio of RNA to DNA, as well as ratio of LDH to β-hydroxy-acyl-CoA-dehydrogenase in the PM muscle of pigs. Furthermore, HNI increased percentages of MyHC IIb, mRNA expression of IGF-1, IGF-1R, Akt, mTOR, RPS6, and eIF4E, as well as protein expression of P-mTOR, P-Akt, P-RPS6, and P-eIF4E in the PM muscle of pigs.

CONCLUSION: The present findings suggest that high nutrient intake during the suckling period could improve skeletal muscle growth and maturity, which is associated with increasing the expression of protein deposition-related genes and accelerating the development of glycolytic-type myofiber in pigs.

Keywords: Birth weight; Metabolic status; Nutrient intake; Pigs; Skeletal muscle

Conflict of interest statement

All institutional and national guidelines for the care and use of laboratory animals were followed. The experimental procedures were approved by the Animal Care and Use Committee of Sichuan Agricultur

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