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Kosgodage US, Mould R, Henley AB, et al. Cannabidiol (CBD) Is a Novel Inhibitor for Exosome and Microvesicle (EMV) Release in Cancer. Front Pharmacol. 2018;9:889doi: 10.3389/fphar.2018.00889.
Kosgodage, U. S., Mould, R., Henley, A. B., Nunn, A. V., Guy, G. W., Thomas, E. L., Inal, J. M., Bell, J. D., & Lange, S. (2018). Cannabidiol (CBD) Is a Novel Inhibitor for Exosome and Microvesicle (EMV) Release in Cancer. Frontiers in pharmacology, 9889. https://doi.org/10.3389/fphar.2018.00889
Kosgodage, Uchini S, et al. "Cannabidiol (CBD) Is a Novel Inhibitor for Exosome and Microvesicle (EMV) Release in Cancer." Frontiers in pharmacology vol. 9 (2018): 889. doi: https://doi.org/10.3389/fphar.2018.00889
Kosgodage US, Mould R, Henley AB, Nunn AV, Guy GW, Thomas EL, Inal JM, Bell JD, Lange S. Cannabidiol (CBD) Is a Novel Inhibitor for Exosome and Microvesicle (EMV) Release in Cancer. Front Pharmacol. 2018 Aug 13;9:889. doi: 10.3389/fphar.2018.00889. eCollection 2018. PMID: 30150937; PMCID: PMC6099119.
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Front Pharmacol. 2018 Aug 13;9:889. doi: 10.3389/fphar.2018.00889. eCollection 2018.

Cannabidiol (CBD) Is a Novel Inhibitor for Exosome and Microvesicle (EMV) Release in Cancer.

Frontiers in pharmacology

Uchini S Kosgodage, Rhys Mould, Aine B Henley, Alistair V Nunn, Geoffrey W Guy, E L Thomas, Jameel M Inal, Jimmy D Bell, Sigrun Lange

Affiliations

  1. Cellular and Molecular Immunology Research Centre, School of Human Sciences, London Metropolitan University, London, United Kingdom.
  2. Research Centre for Optimal Health, Department of Life Sciences, University of Westminster, London, United Kingdom.
  3. GW Research, Sovereign House Vision Park, Cambridge, United Kingdom.
  4. School of Life and Medical Sciences, University of Hertfordshire, Hatfield, United Kingdom.
  5. Tissue Architecture and Regeneration Research Group, Department of Biomedical Sciences, University of Westminster, London, United Kingdom.
  6. Department of Pharmacology, University College London School of Pharmacy, London, United Kingdom.

PMID: 30150937 PMCID: PMC6099119 DOI: 10.3389/fphar.2018.00889

Abstract

Exosomes and microvesicles (EMV) are lipid bilayer-enclosed structures, released by cells and involved in intercellular communication through transfer of proteins and genetic material. EMV release is also associated with various pathologies, including cancer, where increased EMV release is amongst other associated with chemo-resistance and active transfer of pro-oncogenic factors. Recent studies show that EMV-inhibiting agents can sensitize cancer cells to chemotherapeutic agents and reduce cancer growth

Keywords: cancer; cannabidiol (CBD); combinatory treatment; exosomes; inflammation; microvesicles (MVs); mitochondria; peptidylarginine deiminase (PAD)

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