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Malakou LS, Gargalionis AN, Piperi C, et al. Molecular mechanisms of mechanotransduction in psoriasis. Ann Transl Med. 2018;6(12):245doi: 10.21037/atm.2018.04.09.
Malakou, L. S., Gargalionis, A. N., Piperi, C., Papadavid, E., Papavassiliou, A. G., & Basdra, E. K. (2018). Molecular mechanisms of mechanotransduction in psoriasis. Annals of translational medicine, 6(12), 245. https://doi.org/10.21037/atm.2018.04.09
Malakou, Lina S, et al. "Molecular mechanisms of mechanotransduction in psoriasis." Annals of translational medicine vol. 6,12 (2018): 245. doi: https://doi.org/10.21037/atm.2018.04.09
Malakou LS, Gargalionis AN, Piperi C, Papadavid E, Papavassiliou AG, Basdra EK. Molecular mechanisms of mechanotransduction in psoriasis. Ann Transl Med. 2018 Jun;6(12):245. doi: 10.21037/atm.2018.04.09. PMID: 30069447; PMCID: PMC6046295.
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Ann Transl Med. 2018 Jun;6(12):245. doi: 10.21037/atm.2018.04.09.

Molecular mechanisms of mechanotransduction in psoriasis.

Annals of translational medicine

Lina S Malakou, Antonios N Gargalionis, Christina Piperi, Evangelia Papadavid, Athanasios G Papavassiliou, Efthimia K Basdra

Affiliations

  1. Cellular and Molecular Biomechanics Unit, Department of Biological Chemistry, Medical School, National and Kapodistrian University of Athens, Athens, Greece.
  2. Second Department of Dermatology, Medical School, National and Kapodistrian University of Athens, 'Attikon' General University Hospital, Athens, Greece.

PMID: 30069447 PMCID: PMC6046295 DOI: 10.21037/atm.2018.04.09

Abstract

Psoriasis is an immune disease of the skin that frequently develops upon triggering events of mechanical nature and leads to increased proliferation and damaged differentiation of keratinocytes of the epidermis. Mechanical forces are mediated through mechanotransduction, which is the process that translates physical cues into biochemical signaling networks. Latest updates underline the role of mechanotransduction during the acquisition of aberrant properties by the keratinocytes of the skin, therefore implying a potential contribution that promotes psoriasis pathogenesis. The present review discusses the mechano-induced signaling pathways and individual molecules that become activated in psoriasis and in keratinocytes, along with mechano-based putative treatment strategies. We also suggest emerging mechanosensitive molecules for further investigation with potential diagnostic and therapeutic utility in psoriasis.

Keywords: Mechanotransduction; TRP channels; Yes-associated/TAZ (YAP/TAZ); polycystin; psoriasis

Conflict of interest statement

Conflicts of Interest: The authors have no conflicts of interest to declare.

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